Evidence map›Paper›PMID 40927681›Full record

ArticleiScience2025

Integrative gene and isoform co-expression networks reveal regulatory rewiring in stress-related psychiatric disorders.

Ghalia Rehawi, Jonas Hagenberg, BeCOME study group, Optima study group, Philipp G Sämann, Lambert Moyon, Elisabeth Binder, Markus List, Annalisa Marsico, Janine Knauer-Arloth

Abstract read
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ghalia RehawiMax Planck Institute of Psychiatry, 80804 Munich, Germany.
Jonas HagenbergMax Planck Institute of Psychiatry, 80804 Munich, Germany.
BeCOME study group
Optima study group
Philipp G SämannMax Planck Institute of Psychiatry, 80804 Munich, Germany.
Lambert MoyonInstitute of Computational Biology, Helmholtz Zentrum München, 85764 Neuherberg, Germany.
Elisabeth BinderMax Planck Institute of Psychiatry, 80804 Munich, Germany.
Markus ListData Science in Systems Biology, TUM School of Life Sciences, Technical University of Munich, 85354 Freising, Germany.
Annalisa MarsicoInstitute of Computational Biology, Helmholtz Zentrum München, 85764 Neuherberg, Germany.
Janine Knauer-ArlothMax Planck Institute of Psychiatry, 80804 Munich, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Isoform-specific expression patterns have been linked to stress-related psychiatric disorders such as major depressive disorder (MDD). To further explore their involvement, we constructed co-expression networks using total gene expression (TE) and isoform ratio (IR) data from affected (

Indexed as

GeneticsMolecular biologyNeuroscienceOmics

Identifiers

PMID40927681
PMCPMC12414837

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.