Trial reportOrthodontics & craniofacial research2025
Randomised Clinical Trial on the Effect of Intermittent Vibrational Force Application During Orthodontic Treatment With Aligners on Root Resorption.
Trial report in Orthodontics & craniofacial research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05316636 (Randomized Clinical Trial on the Effect of Intermittent Vibrational Force Application During Orthodontic Treatment With Aligners on RANKL and OPG Concentrations in Crevicular Fluid), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Clinical Trial on the Effect of Intermittent Vibrational Force Application During Orthodontic Treatment With Aligners on RANKL and OPG Concentrations in Crevicular Fluid
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectiveThe aim of this RCT was to analyse the relationship between intermittent vibratory forces and external apical root resorption (EARR) in patients treated with clear aligners, building on prior research on vibrational effects on biomarkers. MATERIALS AND
methodsA parallel, three-arm randomised clinical trial included adults to be treated with clear aligners, randomly assigned by a computerised randomisation list to: Group A (vibration from treatment onset), Group B (vibration after 6 weeks), or Group C (no vibration). While patients and orthodontists were aware of group assignments, evaluators remained blinded. Digital orthopantomographs (OPGs) taken at treatment initiation (T0) and completion (T4) were analysed using Linge & Linge, Fritz & Krieger, and Malmgren methods. Crevicular fluid levels of receptor activator of nuclear factor-kappa B ligand (RANKL) and osteoprotegerin (OPG) were measured as bone remodelling markers at different time points (T0, T1, T2, T3, T4).
resultsFifteen patients were analysed in Groups A and C, and 14 in Group B. No significant differences in EARR were found between groups, except for a significant increase in Group B (T2-T0) using Fritz & Krieger correlated with OPG (p = 0.010). Mean EARR was 4.13% (Group A), 4.08% (Group B), and 2.52% (Group C) using Linge & Linge; and 3.26%, 2.82%, and 2.12%, respectively, using Fritz & Krieger. No adverse effects were observed.
conclusionThe effect of intermittent vibratory forces on EARR remains inconclusive, highlighting the need for further research to optimise vibration protocols and understand its impact.
trial registrationClinicalTrials.gov identifier: NCT05316636.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.