Evidence map›Paper›PMID 40928383›Full record

GuidelineInternational journal of surgery (London, England)2026

Expert consensus regarding the clinical application of liver contrast-enhanced US with Sonazoid (Sonazoid CEUS).

Jianhua Zhou, Lingling Li, Kun Yan, Yuanyi Zheng, Tian'An Jiang, Huixiong Xu, Jingyong Xu, Xiang Jing, Haitao Ran, Yu Li and 41 more

Abstract readConsensus StatementPractice GuidelineReview
PubMed Full text at PMC Publisher
In one paragraph

Guideline in International journal of surgery (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

51 authors.

Jianhua ZhouDepartment of Ultrasound, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, China.ORCID 0000-0003-2096-8126
Lingling LiDepartment of Ultrasound, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, China.
Kun YanDepartment of Ultrasound, Peking University Cancer Hospital, Beijing, China.
Yuanyi ZhengDepartment of Ultrasound in Medicine, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Tian'An JiangDepartment of Ultrasound, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Huixiong XuDepartment of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China.
Jingyong XuDepartment of General Surgery, Beijing Hospital, Beijing, China.
Xiang JingDepartment of Ultrasound, Tianjin Third Central Hospital, Tianjin, China.
Haitao RanDepartment of Ultrasound, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yu LiDepartment of Ultrasound, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, China.
Wen ChengDepartment of Ultrasound, Harbin Medical University Cancer Hospital, Harbin, China.
Xin-Wu CuiDepartment of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Hong DingDepartment of Ultrasound, Huashan Hospital, Fudan University, Shanghai, China.
Jianmin DingDepartment of Ultrasound, Tianjin Third Central Hospital, Tianjin, China.
Yi DongDepartment of Ultrasound, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
Wenbin DuanDepartment of Hepatobiliary Surgery, the People's Hospital of Hunan Province, Changsha, Hunan, China.
Hong HanDepartment of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China.
Guangzhi HeDepartment of Ultrasound, Shenzhen Guangming New District People's Hospital, Shenzhen, China.
Wei HeDepartment of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China.
Zhongqian HuDepartment of Ultrasound, Zhongda Hospital, Southeast University, Nanjing, China.
Ying HuangDepartment of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China.
Binkui LiDepartment of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China.
Jie LiDepartment of Ultrasound, Qilu Hospital, Shandong University, Jinan, China.
Kai-Yan LiDepartment of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Qian LiDepartment of Ultrasound, Henan Cancer Hospital, Henan, China.
Fangyi LiuDepartment of Interventional Ultrasound, Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
Guang-Jian LiuDepartment of Medical Ultrasonics, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Liping LiuDepartment of Ultrasound Intervention, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Baoming LuoDepartment of Ultrasound, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Wen LuoDepartment of Ultrasound, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, China.
Yan LuoDepartment of Ultrasound, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Ke LvDepartment of Ultrasound, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Xuan MengDepartment of Hepatobiliary Surgery, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Li QiuDepartment of Ultrasound, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, China.
Jie RenDepartment of Medical Ultrasonics, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Hongguang WangDepartment of Hepatobiliary Surgery, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Lijun WangDepartment of Hepatopancreatobiliary Surgery Unit I, Peking University Cancer Hospital & Institute, Beijing, China.
Xi WeiDepartment of Ultrasound Diagnosis and Treatment, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Wei WuDepartment of Ultrasound, Peking University Cancer Hospital, Beijing, China.
Xiao-Yan XieDepartment of Medical Ultrasonics, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Baocai XingDepartment of Hepatic & Biliary Surgery, Peking University Cancer Hospital & Institute, Beijing, China.
Dong XuDepartment of Diagnostic Ultrasound Imaging & Interventional Therapy, Zhejiang Cancer Hospital, Hangzhou, China.
Hong YangDepartment of Medical Ultrasound, First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Jianhui YangDepartment of Hepatobiliary Surgery, the People's Hospital of Hunan Province, Changsha, Hunan, China.
Meng YangDepartment of Ultrasound, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Jie YuDepartment of Interventional Ultrasound, Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
Ming-An YuDepartment of Interventional Medicine, China-Japan Friendship Hospital, Beijing, China.
Xiaoling YuDepartment of Interventional Ultrasound, Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
Wei ZhengDepartment of Ultrasound, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, China.
Zu-Bang ZhouDepartment of Ultrasound Medicine, Gansu Provincial People's Hospital, Lanzhou, China.
Ping LiangDepartment of Interventional Ultrasound, Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.ORCID 0000-0001-8933-6392

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sonazoid, a combined blood pool and Kupffer-cell agent, can be specifically phagocytosed by Kupffer cells in the liver, allowing lesion detection and characterization of focal liver lesions (FLLs) at the post-vascular phase, apart from the vascular phase, which is similar to that of other second-generation ultasound (US) contrast agents. Sonazoid contrast-enhanced US (CEUS) is currently approved for use in some Asian countries. With the increasing use of Sonazoid CEUS for FLLs in clinical practice, developing consensus or guidelines to help standardize its use is required. The expert consensus aimed to review recent evidence and make evidence-based recommendations for radiologists and clinicians involved in the management of liver diseases regarding the use of Sonazoid CEUS in the surveillance or detection, characterization of FLLs, CEUS for interventional and intraoperative use, and tumor treatment response evaluation in patients with FLLs. This consensus was conducted without using artificial intelligence tools in accordance with the TITAN Guidelines 2025.

Indexed as

Contrast MediaFerric CompoundsIronLiver DiseasesOxidesConsensusHumansLiverLiver NeoplasmsUltrasonographyContrast MediaFerric CompoundsIronOxidesSonazoidconsensus statementcontrast-enhanced USliverSonazoid

Identifiers

PMID40928383
PMCPMC12825900

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.