Evidence map›Paper›PMID 40928728›Full record

ArticleMolecular biology reports2025

Mycoplasma ovipneumoniae infection inhibits scavenger receptor A-mediated phagocytosis of Pasteurella multocida in alveolar macrophages.

Guangxin Zhao, Xinyan Cao, Guojie Cheng, Gang Wang, Sun He, Jinliang Sheng, Yanming Sun, Yanbing Zhang

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Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Guangxin Zhao *College of Animal Science and Technology, Shihezi University, Shihezi, 832003, China.
Xinyan Cao *College of Animal Science and Technology, Shihezi University, Shihezi, 832003, China.
Guojie ChengCollege of Animal Science and Technology, Shihezi University, Shihezi, 832003, China.
Gang WangTECON Pharmaceutical Co. Ltd, Urumqi, 830052, China.
Sun HeTECON Pharmaceutical Co. Ltd, Urumqi, 830052, China.
Jinliang ShengCollege of Animal Science and Technology, Shihezi University, Shihezi, 832003, China.
Yanming SunCollege of Animal Science and Technology, Shihezi University, Shihezi, 832003, China. sym@shzu.edu.cn.
Yanbing ZhangCollege of Animal Science and Technology, Shihezi University, Shihezi, 832003, China. zhangyanbing@shzu.edu.cn.

Funding

National Natural Science Foundation of China 32360901, 32060133Natural Science Foundation of Xinjiang 2023LQ03003, 2022D01B197Xinjiang Corps Guiding Science and Technology Plan Project 2023ZD042
6 · The paper itself

Abstract

backgroundA secondary Pasteurella multocida (Pm) infection following Mycoplasma ovipneumoniae (Mo) challenge in sheep results in severe respiratory disease. Scavenger receptor A (SRA) is a key phagocytic receptor on macrophages, which facilitates microbial clearance. However, the role of sheep SRA in Mo-associated secondary Pm infection is less understood. METHODS AND

resultsThe expression of SRA was found to be the highest in alveolar macrophages (AMs) compared with lung tissue and spleen using quantitative polymerase chain reaction. Also, SRA was expressed in various tissues of sheep. SRA overexpression significantly enhanced Pm uptake by CHO cells, whereas fucoidan (a type A scavenger receptor-specific blocker) markedly reduced bacterial phagocytosis by AMs. This indicated an essential role of sheep SRA in macrophage phagocytosis of Pm. However, Mo infection downregulated SRA expression and impaired AM-mediated phagocytosis of Pm; this effect was reversed by SRA overexpression. Furthermore, we presumed that this might be due to the inhibition of SRA expression by tumor necrosis factor-alpha and interleukin 6, thereby suppressing SRA-dependent phagocytosis.

conclusionsThe findings of this study elucidate the role of SRA in Mo-induced secondary Pm infection and provide some support for in-depth exploration in subsequent studies.

Indexed as

Macrophages, AlveolarMycoplasma ovipneumoniaePasteurella multocidaPhagocytosisPneumonia, MycoplasmaScavenger Receptors, Class AAnimalsCHO CellsCricetulusInterleukin-6Pasteurella InfectionsSheepSheep DiseasesTumor Necrosis Factor-alphaInterleukin-6Scavenger Receptors, Class ATumor Necrosis Factor-alphaAlveolar macrophagesImmune evasionMycoplasma ovipneumoniaePasteurella multocidaScavenger receptor A

Identifiers

PMID40928728

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.