ArticleScience advances2025
Single-cell multiome and spatial profiling reveals pancreas cell type-specific gene regulatory programs of type 1 diabetes progression.
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Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20citing papers in PubMed
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Who cites it
20 citing papers in PubMed.
- Interleukin-1 mediates innate immune signaling and antiviral defense in islets.Life science alliance · 2026Article
- Understanding development and cellular plasticity in the pancreas in health and disease.Nature reviews. Gastroenterology & hepatology · 2026Review
- Applications of Stem Cell-Derived Islets and Emerging Experimental Platforms to Understand Diabetes.Diabetes · 2026Review
- Oxidative Post-Translational Modifications of Insulin in Type 1 Diabetes Autoimmunity.Immunological reviews · 2026Review
- Spatially resolved tissue architecture and computational pathology in pancreatic cancer.Experimental & molecular medicine · 2026Review
- A 3D spatial proteomic map of the human pancreatic islet microenvironment.Research square · 2026Article
- PanKbase Integrated Single-Cell Map: A Comprehensive Atlas of Human Pancreatic Islets.bioRxiv : the preprint server for biology · 2026Article
- Condition-Associated Pattern Extraction and Recovery From Multi-Condition Single-Cell RNA-seq Data With CAPER.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Sensing and Communicating β-Cell Stress in the Context of T1D Etiology: New Opportunities for Therapeutic Impact.Comprehensive Physiology · 2026Review
- A surviving beta cell subpopulation enriched in patients with T1D.bioRxiv : the preprint server for biology · 2026Article
- Activation of the Pancreatic "Metabolic Synapse" Aggravates Type 2 Diabetes Mellitus by Inducing PANoptosis in β-Cells.Diabetes · 2026Article
- Activated Human Pancreatic Stellate Cells SignatureCommunication in Type 1 Diabetes.Research square · 2026Article
- Materials and System Design for Self-Decision Bioelectronic Systems.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Causal Risk Factors for Type 1 Diabetes in Mendelian Randomization Studies: A Systematic Review and Meta-Analysis.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Review
- From islet to blood: macrophage remodeling signatures for diagnosis and risk stratification in type 1 diabetes.Frontiers in immunology · 2026Article
- Decoding type 5 diabetes using spatial omics: microarchitectural and molecular mechanisms of malnutrition-associated diabetes.Frontiers in endocrinology · 2026Review
- Single cell and spatial characterization of the human pancreas reveals drivers of beta cell dysfunction in cystic fibrosis.bioRxiv : the preprint server for biology · 2025Article
- Single-Islet Proteomics Maps Pseudo-Temporal Islet Immune Responses and Dysfunction in Stage 1 Type 1 Diabetes.bioRxiv : the preprint server for biology · 2025Article
- CFTR Gene Regulation in Human Pancreatic Duct, Bile Duct and Sweat Gland Epithelial Cells.Journal of cellular and molecular medicine · 2025Article
- Circulating pancreatic enzyme levels are a causal biomarker of type 1 diabetes.medRxiv : the preprint server for health sciences · 2024Article
Corrections and comments
- Update of
Authors and funding
23 authors.
Rebecca MeltonBiomedical Sciences Program, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0003-3219-5773
Sara JimenezDepartment of Computational Health, Institute of Computational Biology, Helmholtz, Munich, Germany.ORCID 0000-0001-7103-7474
Weston ElisonBiomedical Sciences Program, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-5496-2972
Luca TucciaroneDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.
Abigail HowellDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.
Gaowei WangDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.
Denise BertiDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.ORCID 0009-0003-2196-9240
Elisha BeebeDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.ORCID 0009-0006-4921-7827
Michael MillerCenter for Epigenomics, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0003-0781-7868
Chun ZengDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.
Carolyn McGrailBiomedical Sciences Program, University of California San Diego, La Jolla, CA, USA.
Kennedy VanderStelDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.
Katha KorgaonkarDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.
Ruth ElgamalBiomedical Sciences Program, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0001-9183-9386
Hannah MummeyBioinformatics and Systems Biology Program, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-7663-8559
Joshua ChiouPfizer Research and Discovery, Pfizer Inc., Cambridge, MA, USA.ORCID 0000-0002-4618-0647
Emily GriffinDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.
Irina KusmartsevaDepartment of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, USA.
Mark AtkinsonDepartment of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, USA.ORCID 0000-0001-8489-4782
Sebastian PreisslCenter for Epigenomics, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0001-8971-5616
Fabian J TheisDepartment of Computational Health, Institute of Computational Biology, Helmholtz, Munich, Germany.ORCID 0000-0002-2419-1943
Maike SanderDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.
Kyle J GaultonDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0003-1318-7161
Funding
The Human Pancreas Analysis Program for Type 2 DiabetesU01DK123594 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Robert Babak Faryabi, KLAUS H KAESTNER · 2019 to 2026
$25.0MPenn integrated Human Pancreas procurement and Analysis ProgramUC4DK112217 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI BETTS, MICHAEL R, FELDMAN, MICHAEL D · 2016 to 2020
$17.8MSupplement to Integrated Program for Human Pancreas Procurement and AnalysisUC4DK112232 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ATKINSON, MARK A., POWERS, ALVIN C · 2016 to 2020
$8.4MHuman Pancreas Analysis Program-T2DU01DK123716 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ATKINSON, MARK A., BOTTINO, RITA · 2019 to 2024
$6.6MGenetic mechanisms of type 1 diabetes risk in stress-induced pancreatic isletsR01DK122607 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GAULTON, KYLE JEFFRIE · 2019 to 2022
$4.4MSingle cell analysis of the human pancreas in type 1 diabetesU01DK120429 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GAULTON, KYLE JEFFRIE, SANDER, MAIKE · 2018 to 2021
$3.1MUC San Diego Genetics Training ProgramT32GM145427 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRUCE A HAMILTON · 2022 to 2026
$2.6MNIDDK NIH HHS R01 DK122607NIDDK NIH HHS U01 DK120429NIDDK NIH HHS U01 DK123594NIDDK NIH HHS U01 DK123716NIDDK NIH HHS UC4 DK112217NIDDK NIH HHS UC4 DK112232NIGMS NIH HHS T32 GM145427
Abstract
Cell type-specific regulatory programs that drive type 1 diabetes (T1D) in the pancreas are poorly understood. Here, we performed single-nucleus multiomics and spatial transcriptomics in up to 32 nondiabetic (ND), autoantibody-positive (AAB
Indexed as
Diabetes Mellitus, Type 1Gene Expression RegulationGene Regulatory NetworksPancreasSingle-Cell AnalysisAutoantibodiesDisease ProgressionFemaleGene Expression ProfilingHumansInsulin-Secreting CellsMaleTranscriptomeAutoantibodies
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