Trial reportAnnals of the American Thoracic Society2025
Nocturnal Oxygen Therapy for Central Sleep Apnea in Patients with Heart Failure: A Multisite, Double-Blind, Sham-controlled Randomized Clinical Trial (LOFT-HF).
Abstract readRandomized Controlled TrialMulticenter Study
In one paragraph
Trial report in Annals of the American Thoracic Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Oxygen overshoot burden of central sleep apnea and its association with cardiovascular outcomes.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Article
- The 2025 American Academy of Sleep Medicine Central Sleep Apnoea Guidelines and the Heart Failure Patient.Cardiac failure review · 2026Review
- When LOFTy Ideals Meet Clinical Trial Reality.Annals of the American Thoracic Society · 2025Article
Corrections and comments
- Commented on by
Authors and funding
34 authors.
Susan RedlineDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.ORCID 0000-0002-6585-1610
Dongdong LiDepartment of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, Massachusetts.
Shahrokh JavaheriDivision of Pulmonary and Sleep Medicine, Bethesda North Hospital, Cincinnati, Ohio.
Sanjay R PatelDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.ORCID 0000-0002-9142-5172
Sairam ParthasarathyDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Arizona, Tucson, Arizona.
James C FangDivision of Cardiovascular Medicine, Department of Medicine, University of Utah, Salt Lake City, Utah.
Lee K BrownDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico.
Mark DunlapDepartment of Medicine, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio.
M Safwan BadrDepartment of Medicine, School of Medicine, Wayne State University, Detroit, Michigan.
Neomi ShahDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
Luqi ChiDepartment of Neurology, Sleep Medicine Center, and.
Ruckshanda MajidDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, McGovern Medical School, UT Health, Houston, Texas.
Mihaela TeodorescuDepartment of Medicine and Wisconsin Institute for Sleep and Consciousness and.
Garrick StewartDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Eileen HsichDepartment of Medicine, Cleveland Clinic Foundation, Cleveland, Ohio.
Tamar PolonskySection of Cardiology, Department of Medicine, University of Chicago, Chicago, Illinois.
Justin VaderCardiology Division, Department of Internal Medicine, School of Medicine, Washington University, St. Louis, Missouri.
Maryl R JohnsonDepartment of Medicine, Heart Failure and Transplant Cardiology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin.
Dennis AuckleyDepartment of Medicine, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio.
Henry Klar YaggiDepartment of Medicine, Yale University, New Haven, Connecticut.
Andrew KaoSt. Luke's Mid America Heart Institute, Kansas City, Missouri.
Ali AzarbarzinDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Raichel AlexDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Michael RueschmanDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Lisa WolfeFeinberg School of Medicine, Northwestern University, Chicago, Illinois.
Daniel J GottliebDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Scott A SandsDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.ORCID 0000-0003-3752-0328
Phyllis C ZeeDepartment of Neurology.
Reena MehraDivision of Pulmonary, Critical Care and Sleep Medicine, University of Washington, Seattle, Washington.
Babak MokhlesiDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois.
Rami KhayatDivision of Pulmonary, Allergy, and Critical Care, College of Medicine, Pennsylvania State University, Hershey, Pennsylvania.
Eldrin F LewisDivision of Cardiology, Department of Medicine, Stanford University, Palo Alto, California; and.
William T AbrahamDivision of Cardiovascular Medicine and Davis Heart and Lung Research Institute, College of Medicine and Wexner Medical Center, The Ohio State University, Columbus, Ohio.
Rui WangDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Funding
Impact of Low Flow Nocturnal Oxygen Therapy On Hospital Admissions and Mortality in Patients with Heart Failure and Central Sleep Apnea - DCCU24HL140412 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI REDLINE, SUSAN S., WANG, RUI · 2018 to 2020
$3.1MImpact of Low Flow Nocturnal Oxygen Therapy On Hospital Readmission/Mortalityin Patients with Heart Failure and Central Sleep Apneal (LOFT-HF)UG3HL140144 · NHLBI · OHIO STATE UNIVERSITY · PI ABRAHAM, WILLIAM TOBER · 2018 to 2018
$742kNHLBI NIH HHS U24 HL140412NHLBI NIH HHS U24HL140412NHLBI NIH HHS UG3 HL140144NHLBI NIH HHS UG3HL140144
Abstract
PubMed holds no abstract for this paper.
Indexed as
Heart FailureOxygen Inhalation TherapySleep Apnea, CentralAgedDouble-Blind MethodFemaleHumansMaleMiddle AgedPolysomnographyQuality of LifeStroke VolumeTreatment Outcomecentral sleep apneaclinical trialheart failureHunter-Cheyne-Stokes breathingoxygen
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.