Evidence map›Paper›PMID 40930069›Full record

ArticleStem cell reports2025

Ectopic recruitment of neuroblasts in striatal myelin bundles and nucleus accumbens following AraC chemical lesion.

Irini Thanou, Paraskevi N Koutsoudaki, Maria Margariti, Federico Luzzati, Sophia Havaki, Vassilis G Gorgoulis, Dimitra Thomaidou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Irini ThanouNeural Stem Cells and Neuroimaging Group, Department of Neurobiology, Hellenic Pasteur Institute, 11521 Athens, Greece.
Paraskevi N KoutsoudakiMolecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Maria MargaritiNeural Stem Cells and Neuroimaging Group, Department of Neurobiology, Hellenic Pasteur Institute, 11521 Athens, Greece.
Federico LuzzatiDepartment of Life Sciences and Systems Biology (DBIOS), University of Turin, Turin 10123, Italy Neuroscience Institute Cavalieri Ottolenghi (NICO), 10043 Orbassano, Italy.
Sophia HavakiMolecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Vassilis G GorgoulisMolecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece; Biomedical Research Foundation, Academy of Athens, Athens, Greece; Ninewells Hospital and Medical School, University of Dundee, Dundee, UK; Faculty Institute for Cancer Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK; Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.
Dimitra ThomaidouNeural Stem Cells and Neuroimaging Group, Department of Neurobiology, Hellenic Pasteur Institute, 11521 Athens, Greece. Electronic address: thomaidou@pasteur.gr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the adult brain, neural stem cells (NSCs) constitutively generate new neurons in specific neurogenic domains. Recent research has unveiled reactive neurogenesis, whereby brain injury triggers NSC activation, enhancing their differentiation potential and guiding progeny to injured areas. Our study provides evidence of alternative migration pathways for newborn neurons in the mouse subcortical forebrain, revealed by administration of a chemotherapeutic agent. This allows a high number of newborn neurons to migrate long distances over an extended period. Notably, a subpopulation of neuroblasts diverts from the canonical SVZ-olfactory bulb (OB) rostral migratory stream toward the striatum (STR), with distinct localization along striatal myelin tracts and through nucleus accumbens (NAc) to the anterior commissure (AC). This neuroblast (NB) rerouting is accompanied by with oligodendrocyte lineage dysregulation and myelin deficits, suggesting a link between ectopic NB presence and observed myelin abnormalities.

Indexed as

Corpus StriatumMyelin SheathNeural Stem CellsNucleus AccumbensAnimalsCell DifferentiationCell MovementMiceNeurogenesisNeuronsOlfactory BulbOligodendrogliaadult neurogenesisAraCectopic migrationlesion-induced neurogenesismyelin bundlesneuroblastsstriatumsubventricular zone

Identifiers

PMID40930069
PMCPMC12447329

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.