Evidence map›Paper›PMID 40930991›Full record

ArticleGenes & development2025

Multiple human enhancer RNAs contain long translated open reading frames.

Pavel A Vlasov, Koichi Ogami, Elizabeth Valenzuela, Risa Karakida Kawaguchi, Marko Jovanovic, James L Manley

Abstract read
In one paragraph

Article in Genes & development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Pavel A VlasovDepartment of Biological Sciences, Columbia University, New York, New York 10027, USA.
Koichi OgamiDivision of Molecular Oncology, Graduate School of Medicine, Nagoya University, Showa-ku, Nagoya 466-8550, Japan.ORCID 0000-0001-9380-9666
Elizabeth ValenzuelaDepartment of Biological Sciences, Columbia University, New York, New York 10027, USA.
Risa Karakida KawaguchiDepartment of Life Science Frontiers, Center for iPS Cell Research and Application, Kyoto University, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
Marko JovanovicDepartment of Biological Sciences, Columbia University, New York, New York 10027, USA.
James L ManleyDepartment of Biological Sciences, Columbia University, New York, New York 10027, USA; jlm2@columbia.edu.

Funding

Regulation of RNA processing: Mechanisms and ConsequencesR35GM118136 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI James L. Manley · 2016 to 2026
$8.9M
Extensive multiplexing of protein nucleic-acid interactions to comprehensively study gene expression regulation from chromatin to mRNA degradationR01HG012216 · NHGRI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI GUTTMAN, MITCHELL, JOVANOVIC, MARKO · 2022 to 2025
$3.1M
Defining the programmed proteome rejuvenation underlying gametogenesisR01AG071869 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI BRAR, GLORIA ANN, JOVANOVIC, MARKO · 2021 to 2025
$2.9M
Regulation of Protein Production Dynamics:RNA Binding Proteins and the Ribosome CodeR35GM128802 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI JOVANOVIC, MARKO · 2018 to 2022
$2.3M
NHGRI NIH HHS R01 HG012216NIA NIH HHS R01 AG071869NIGMS NIH HHS R35 GM118136NIGMS NIH HHS R35 GM128802
6 · The paper itself

Abstract

Enhancer RNAs (eRNAs) are transcribed by

Indexed as

Enhancer Elements, GeneticOpen Reading FramesProtein BiosynthesisCell NucleusChromatinEnhancer RNAsHumansChromatinEnhancer RNAsenhancersRNAtranslation

Identifiers

PMID40930991
PMCPMC12667400

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.