ArticleNature2025
Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours.
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Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25citing papers in PubMed
–field-weighted citation impact
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Who cites it
25 citing papers in PubMed.
- DONSON links tumor-cell survival to MIF-associated macrophage remodeling in small cell lung cancer.Apoptosis : an international journal on programmed cell death · 2026Article
- Spatially Distinct Bone Marrow Sites Are Asymmetrically Impacted by Inflammatory Cardiovascular Disease.JACC. Basic to translational science · 2026Article
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- Pathophysiological roles of monocytes and macrophages in cancer.Nature reviews. Immunology · 2026Review
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- BCG HSP70 Reprograms Macrophages via Central Trained Immunity to Suppress Prostate Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Cardiac-targeting peptide-modified Prussian blue nanozymes loaded with Astragaloside IV for efficient ICI-myocarditis therapy.Materials today. Bio · 2026Article
- Environmental exposures and multiple myeloma risk: A contemporary review of epidemiologic associations and mechanistic plausibility.Blood reviews · 2026Review
- Kupffer cells in liver homeostasis and disease: from immune sentinels to metabolic gatekeepers.Nature reviews. Immunology · 2026Review
- NRF2-mediated inhibition of alveolar macrophage MHC II expression during Mycobacterium tuberculosis infection.Cell reports · 2026Article
- Tumor cell ferroptosis in antitumor immunity and immunotherapy efficacy.Journal for immunotherapy of cancer · 2026Review
- Harnessing myeloid cell plasticity for cancer therapy.Nature cancer · 2026Review
- Albumin-Bound STING Agonist Reprograms HSPCs to Antitumor Neutrophils Enhancing CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Immune Checkpoint Inhibitors and Immunomodulators for Cancer Immunotherapy: Insights Into Resistance and Therapeutic Strategies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Comparative single cell analysis of wound and cancer identifies the metabolic dialogues between tumor initiating stem cells and macrophages.bioRxiv : the preprint server for biology · 2026Article
- Macrophages: Targets for next-generation cancer immunotherapy.Cancer cell · 2026Review
- Genome Agnostic Reprogramming of Acute Myelocytic Leukemia Hallmarks by Targeting Non-Oncogene Addictions with Azacitidine Plus Pioglitazone and All-Trans Retinoic Acid.International journal of molecular sciences · 2026Review
- Metabolic-Immune Coupling in Urologic Cancers: Macrophage Reprogramming as a Therapeutic Nexus.International journal of biological sciences · 2026Review
- Nano-Immunotherapy Targeting TAMs: Precisely Regulating TAMs to Reverse Immunosuppressive TME.International journal of nanomedicine · 2026Review
- Article
Corrections and comments
- Update of
Authors and funding
34 authors.
Samarth HegdeMarc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Bruno Giotti *Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Brian Y Soong *Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0003-4647-7704
Laszlo HalaszMarc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jessica Le BerichelMarc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Maximilian M SchaeferMarc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-6038-7847
Benoit KloecknerInstitut Gustave Roussy, INSERM U1015, Villejuif, France.
Raphaël MattiuzMarc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-3292-1635
Matthew D ParkMarc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Assaf MagenMarc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Adam MarksMarc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Meriem BelabedMarc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Pauline HamonMarc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-6776-1635
Theodore ChinMarc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Leanna TroncosoMarc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0003-2529-9267
Juliana J LeeDepartment of Immunology, Harvard Medical School, Boston, MA, USA.
Kaili FanDepartment of Stem Cell and Regenerative Biology, Harvard Medical School, Boston, MA, USA.
Dughan AhimovicImmunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA.ORCID 0000-0002-5849-335X
Michael J BaleImmunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA.
Kai NieMarc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Grace ChungMarc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-7101-6865
Darwin D'souzaMarc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Krista AngeliadisMarc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Seunghee Kim-SchulzeMarc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0003-0192-4400
Raja M FloresThe Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Andrew J KaufmanThe Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Florent GinhouxInstitut Gustave Roussy, INSERM U1015, Villejuif, France.
Jason D BuenrostroDepartment of Stem Cell and Regenerative Biology, Harvard Medical School, Boston, MA, USA.
Steven Z JosefowiczImmunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA.ORCID 0000-0001-7453-779X
Alexander M TsankovMarc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-7955-4414
Thomas U MarronMarc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-5903-8191
Sai MaDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-9785-7929
Brian D BrownMarc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-3670-8778
Miriam MeradMarc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. miriam.merad@mssm.edu.ORCID 0000-0002-4481-7827
Funding
Investigating Macrophage Molecular and Functional Diversity in Tumor ImmunityR01CA254104 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BROWN, BRIAN D, MERAD, MIRIAM · 2021 to 2025
$3.4MType 2 immunity: a primitive response to epithelial injury that shapes bone marrow and lung myeloid crosstalkR01CA277479 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MIRIAM MERAD, Thomas Urban Marron · 2023 to 2026
$2.6MDefining the barriers to immune surveillance in solid tumorsK00CA223043 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HEGDE, SAMARTH · 2020 to 2023
$374kDeconstructing pathogenic myelopoiesis in cancer immunosuppression and treatment resistanceK99CA293148 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HEGDE, SAMARTH · 2025 to 2025
$147kNCI NIH HHS K00 CA223043NCI NIH HHS K99 CA293148NCI NIH HHS R01 CA254104NCI NIH HHS R01 CA277479
Abstract
Monocyte-derived macrophages (mo-macs) often drive immunosuppression in the tumour microenvironment (TME)
Indexed as
Immune ToleranceImmunosuppression TherapyLung NeoplasmsMacrophagesMyeloid Progenitor CellsTumor MicroenvironmentAnimalsCell DifferentiationEpigenesis, GeneticFemaleHumansKiller Cells, NaturalMaleMiceMice, Inbred C57BLMonocytesNfe2l2 protein, mouseNF-E2-Related Factor 2
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.