Evidence map›Paper›PMID 40931394›Full record

Trial reportObesity (Silver Spring, Md.)2025

Adaptive Thermogenesis After Hypocaloric Low-Carbohydrate Versus Low-Fat Diets in African American Women: A Secondary Analysis.

Silvia Y Lopez Torres, Barbara A Gower, W Timothy Garvey, Catia Martins

Registry-linked trialAbstract readRandomized Controlled TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Obesity (Silver Spring, Md.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03499509 (Obesity Risk in African American Women is Determined by a Diet-by-phenotype Interaction), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03499509 nacompletednot on this map

Obesity Risk in African American Women is Determined by a Diet-by-phenotype Interaction

TypeinterventionalSponsorUniversity of Alabama at BirminghamRan2019 to 2024Enrolled67ConditionsDiet ModificationArmsLow Glycemic Diet, High Glycemic Diet
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Silvia Y Lopez TorresDepartment of Nutrition Sciences, University of Alabama at Birmingham (UAB), Birmingham, Alabama, USA.ORCID https://orcid.org/0009-0003-8234-1318
Barbara A GowerDepartment of Nutrition Sciences, University of Alabama at Birmingham (UAB), Birmingham, Alabama, USA.
W Timothy GarveyDepartment of Nutrition Sciences, University of Alabama at Birmingham (UAB), Birmingham, Alabama, USA.ORCID https://orcid.org/0000-0003-0822-0860
Catia MartinsDepartment of Nutrition Sciences, University of Alabama at Birmingham (UAB), Birmingham, Alabama, USA.ORCID https://orcid.org/0000-0002-4560-0013

Funding

UAB Nutrition Obesity Research Center (NORC)P30DK056336 · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2000 to 2025
$6.0M
UAB Diabetes Research CenterP30DK079626 · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2025 to 2025
$1.3M
UAB Pre-Doctoral Training Program in Obesity-Related ResearchT32HL105349 · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2025 to 2025
$418k
DRC NIDDK P30DK079626NHLBI NIH HHS T32 HL105349NIDDK NIH HHS P30 DK056336NIDDK NIH HHS P30 DK079626NIDDK NIH HHS R01 DK115483NIDDK NIH HHS R01DK115483NORC NIDDK P30DK56336T32 NHLBI T32HL105349
6 · The paper itself

Abstract

objectiveThis secondary analysis was conducted to compare the magnitude of adaptive thermogenesis (AT) following hypocaloric low-carbohydrate (CHO) versus low-fat diets in African American (AA) women.

methodsSixty-nine AA women with obesity were randomized to low-CHO or low-fat hypocaloric diets for 10 weeks, followed by a 4-week weight stabilization period (all food provided). At baseline and Week 13, insulin sensitivity (S

resultsForty women finished the intervention, with an average weight loss of 6.3 ± 3.9 kg and no differences between groups. AT was present at the level of REE (-75 ± 136 kcal/day, p < 0.003, n = 38), but not TEE (-80 ± 288 kcal/day, p = 0.086, n = 40) at Week 13. Women with low S

conclusionsAA women with low S

trial registrationClinicalTrials.gov Identifier: NCT03499509 https://clinicaltrials.gov/study/NCT03499509.

Indexed as

Black or African AmericanDiet, Carbohydrate-RestrictedDiet, Fat-RestrictedObesityThermogenesisAdaptation, PhysiologicalAdultBody CompositionCaloric RestrictionDiet, ReducingEnergy MetabolismFemaleHumansInsulin ResistanceMiddle AgedWeight Lossenergy expenditureglycemic indexmacronutrient compositionmetabolic adaptationweight loss

Identifiers

PMID40931394
PMCPMC12559781

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.