Evidence map›Paper›PMID 40931544›Full record

ArticleMagnetic resonance in medicine2026

Repeatability of diffusion-weighted arterial spin labeling MRI for mapping blood-brain barrier water exchange rate at different postlabel delays.

Yufei D Zhu, Quimby N Lee, Xingfeng Shao, Youngkyoo Jung, Danny J J Wang, Audrey P Fan

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Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Yufei D ZhuDepartment of Biomedical Engineering, University of California, Davis, Davis, California, USA.ORCID 0009-0003-3625-9807
Quimby N LeeDepartment of Neurology, University of California, Davis, Davis, California, USA.
Xingfeng ShaoStevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, California, USA.
Youngkyoo JungDepartment of Radiology, University of California, Davis, Davis, California, USA.
Danny J J WangStevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, California, USA.
Audrey P FanDepartment of Biomedical Engineering, University of California, Davis, Davis, California, USA.

Funding

UC Davis Clinical and Translational Science CenterUL1TR001860 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KENYON, NICHOLAS J., LYLES, COURTNEY REES · 2016 to 2025
$47.3M
Imaging of brain oxygen extraction fraction in vascular contributions to dementiaR01NS128179 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Audrey Peiwen Fan · 2023 to 2026
$2.6M
Non-invasive MRI mapping of BBB water exchange rate and permeabilityR01NS134712 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Danny JJ WANG · 2024 to 2026
$2.1M
NCATS NIH HHS UL1 TR001860NIH HHS R01NS128179NIH HHS R01NS134712NIH HHS UL1 TR001860 (linked award TL1 TR001861)NINDS NIH HHS R01 NS128179
6 · The paper itself

Abstract

purposeThis study sought to determine the intrasession repeatability of the diffusion-weighted (DW) arterial spin labeling (ASL) sequence at different postlabel delays (PLDs).

methodsWe first performed numerical simulations to study the accuracy of the two-compartment water exchange rate (Kw) fitting model with added Gaussian noise for DW PLDs at 1500, 1800, and 2100 ms. Ten young, healthy participants then underwent a structural T

resultsSimulation results showed that the Kw fitting model performed at an error rate less than 10% at physiological ATTs and Kw values, but that error and bias increased at a PLD of 2100 ms and at ATT ranges where the overall blood signal fraction (A

conclusionOverall, DW ASL provides the strongest intrasession repeatability at a PLD of 1800 ms in young, healthy subjects, and a simulation study shows accurate Kw fits at physiologic range of ATTs and Kw values.

Indexed as

Blood-Brain BarrierDiffusion Magnetic Resonance ImagingAdultBrainCerebrovascular CirculationComputer SimulationFemaleHumansImage Processing, Computer-AssistedMaleReproducibility of ResultsSpin LabelsWaterYoung AdultSpin LabelsWaterblood–brain barrierdiffusion‐weighted arterial spin labelingwater exchange rate

Identifiers

PMID40931544
PMCPMC12938883

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.