ArticleBrain and behavior2025
Effects of the Probiotics Lactobacillus rhamnosus DM163 and Lactobacillus delbrueckii DPUL-F36 on Anxiety-Related and Emotional Behaviors in Male Wistar Rats Under an Altered Light-Dark Cycle.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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2 citing papers in PubMed.
- Nutritional Interventions for Enhancing Sleep Quality: The Role of Diet and Key Nutrients in Regulating Sleep Patterns and Disorders.Food science & nutrition · 2025Review
- Effects of the Probiotics Lactobacillus rhamnosus DM163 and Lactobacillus delbrueckii DPUL-F36 on Anxiety-Related and Emotional Behaviors in Male Wistar Rats Under an Altered Light-Dark Cycle.Brain and behavior · 2025Article
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5 authors.
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Abstract
introductionAnxiety and stress are prevalent mental health issues. Traditional drug treatments often come with unwanted side effects and may not produce the desired results. As an alternative, probiotics are being used as a treatment option due to their lack of specific side effects. Probiotics are live microorganisms that, in sufficient amounts, benefit the host's health. The human digestive tract naturally contains hundreds of different types of bacteria; among these bacteria, probiotic strains of Lactobacillus rhamnosus DM163 and Lactobacillus delbrueckii DPUL-F36 are among the species that may improve behavioral disorders such as anxiety and stress.
methodsIn this study, 42 adult male Wistar rats (190-220 gr/BW), categorized into six groups, were used. Except for the control group, the rest were subjected to 30 days of light-dark cycle alteration (4 h dark, 20 h light). Simultaneously with the light/dark disruption, these groups were gavaged daily doses of 1 × 10
resultsThe comparison of behavioral tests showed that the change in the light-dark cycle caused negative behavioral changes, and the administration of probiotics, particularly L. rhamnosus, was found to be more effective in reducing anxiety and stress levels and improving exploratory behavior compared to L. delbrueckii. The qualitative PCR test also determined that during the 30-day intervention period, L. rhamnosus and L. delbrueckii bacteria were present in the intestinal bacterial flora of rats. DISCUSSION: Changes in the light-dark cycle cause significant disturbances in normal physiology. These alterations are especially evident in the functions of the central nervous system and various behaviors. So, in the long term, it can seriously lead to destructive neurodegenerative alterations of the nervous system. Probably, the increase and predominance of the population of probiotics and the effects of their metabolites using the gut-brain axis will lead to beneficial and even preventive effects.
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