Evidence map›Paper›PMID 40932114›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2026

Rapid Glass-Substrate Digital Light 3D Printing Enables Anatomically Accurate Stroke Patient-Specific Carotid Artery-on-Chips for Personalized Thrombosis Investigation.

Yunduo Charles Zhao, Zihao Wang, Arian Nasser, Allan Sun, Zhao Wang, Yingqi Zhang, Jianfang Ren, Haimei Zhao, Nicole Alexis Yap, Yinyan Wang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yunduo Charles ZhaoSchool of Biomedical Engineering, The University of Sydney, Darlington, NSW, 2008, Australia.
Zihao WangSchool of Biomedical Engineering, The University of Sydney, Darlington, NSW, 2008, Australia.
Arian NasserSchool of Biomedical Engineering, The University of Sydney, Darlington, NSW, 2008, Australia.
Allan SunSchool of Biomedical Engineering, The University of Sydney, Darlington, NSW, 2008, Australia.
Zhao WangSchool of Biomedical Engineering, The University of Sydney, Darlington, NSW, 2008, Australia.
Yingqi ZhangSchool of Biomedical Engineering, The University of Sydney, Darlington, NSW, 2008, Australia.
Jianfang RenSchool of Biomedical Engineering, The University of Sydney, Darlington, NSW, 2008, Australia.
Haimei ZhaoSchool of Biomedical Engineering, The University of Sydney, Darlington, NSW, 2008, Australia.
Nicole Alexis YapSchool of Biomedical Engineering, The University of Sydney, Darlington, NSW, 2008, Australia.
Yinyan WangSchool of Biomedical Engineering, The University of Sydney, Darlington, NSW, 2008, Australia.
Zhiyong LiSchool of Mechanical, Medical and Process Engineering, Faculty of Engineering, Queensland University of Technology, Brisbane, 4001, Australia.
Ken S ButcherPrince of Wales Clinical School, Prince of Wales Hospital, Randwick, NSW, 2031, Australia.
Freda PassamCharles Perkins Centre, The University of Sydney, Camperdown, NSW, 2006, Australia.
Timothy AngDepartments of Interventional Neuroradiology Neurology, Royal Prince Alfred Hospital, Camperdown, NSW, 2006, Australia.
Lining Arnold JuSchool of Biomedical Engineering, The University of Sydney, Darlington, NSW, 2008, Australia.ORCID 0000-0002-7591-0864

Funding

2025 Australian Academy of Science Early- and Mid-Career Researcher Mobility Grants TheRodRickardsFellowships-L.A.J2025 Faculty of Engineering Special Studies Program SSP-L.A.JNational Health and Medical Research Council (NHMRC) of Australia APP2003904 - L.A.JNational Health and Medical Research Council (NHMRC) of Australia GNT2022247 - Y.C.ZNational Heart Foundation of Australia 106879 - Y.C.ZNational Heart Foundation of Australia 106979 - L.A.JNSW Boosting Business Innovation Program (BBIP) International Stream (L.A.J.)NSW Cardiovascular Capacity Building Program (Early-Mid Career Researcher Grant - L.A.J.) APP2016165- L.A.JNSW Cardiovascular Capacity Building Program (Early-Mid Career Researcher Grant - L.A.J.) APP2023977- L.A.JRamaciotti Foundations 2020HIG76 - L.A.JSnow Medical Research Foundation Fellow 2022SF176Wellcome Trust 105863
6 · The paper itself

Abstract

Translating patient-specific vascular geometries into functional microfluidic devices remains challenging due to fabrication limitations and lengthy processing times. Here, an ultrafast microfabrication platform is introduced using glass-substrate digital light processing 3D printing for creating patient-specific carotid artery-on-a-chip devices. The optimized protocol employs treated glass slides as printing substrates and custom-designed mechanical clamping, reducing manufacturing time from over 10 h to under 2 h with ≈100% success rate. The system accurately reproduces complex anatomical features from CT angiography data of stroke patients, including stenoses, bifurcations, and ulcerations that conventional reconstruction methods often miss. Computational fluid dynamics validation confirms preserved hemodynamic similarity between patient-scale and chip-scale geometries, with matched wall shear rates maintaining physiological relevance despite 30-fold size reduction. The platform supports endothelialization and blood perfusion, enabling real-time visualization of thrombotic processes. Integration with laser ablation technology allows controlled endothelial injury modeling at patient-specific vulnerable sites. Quantitative analysis reveals 7-10-fold higher platelet translocation in the high shear zone (>1000 s

Indexed as

Carotid ArteriesGlassLab-On-A-Chip DevicesPrecision MedicinePrinting, Three-DimensionalStrokeThrombosisHumans3D printingbiofabricationorgan‐on‐a‐chipstrokethrombosis

Identifiers

PMID40932114
PMCPMC12822522

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.