ArticleFrontiers in human neuroscience2025
Intermittent theta burst stimulation enhances prefrontal activation and connectivity: evidence from fNIRS.
Article in Frontiers in human neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy of non-invasive neuromodulation technologies in improving cognitive function and activities of daily living in patients with Alzheimer's disease, Parkinson's disease, and stroke: a systematic review and network meta-analysis.Journal of neuroengineering and rehabilitation · 2026Pooled it
- Theta burst stimulation of extrastriate body area for body perception in anorexia nervosa: a randomized controlled trial.Translational psychiatry · 2026Trial
- Transcranial magnetic stimulation combined with functional near-infrared spectroscopy to elucidate the neurophysiological mechanisms of post-stroke hemiplegia: a systematic review.Frontiers in neurologyReview
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5 authors.
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Abstract
Objective: To investigate the neuro-regulatory mechanisms of intermittent theta burst stimulation (iTBS) on prefrontal brain function. Methods: Functional near-infrared spectroscopy (fNIRS) was used to monitor the blood flow dynamics response in the prefrontal cortex of 20 healthy adults. Measurements were taken at five time points (10, 25, 40, 55, and 70 min) after iTBS stimulation, as well as before stimulation (T0). The activation intensity of prefrontal cortex was assessed by quantifying the relative change in oxygenated hemoglobin concentration (β value), and functional connectivity between prefrontal-related brain regions was evaluated by calculating the correlation coefficients of oxygenated hemoglobin concentration between channels across time series for each subject. Results: Compared with the pre-stimulation period, the activation intensity in the prefrontal cortex was significantly higher from 10 to 70 min after iTBS stimulation. Specifically, seven channels showed statistically significant differences, with peak effects occurring 10 min after intervention and gradually attenuating over time. Additionally, compared with T0, the functional connectivity (FC) strength of the prefrontal network was markedly enhanced 10 min after intervention, accompanied by a notable increase in the number of connections between channels. However, the FC strength gradually weakened over time, and no statistically significant differences in FC strength were observed at 55 and 70 min post-intervention. Taken together, We conclude that the neural modulation effects of a single iTBS session persist for ~40 min. These results elucidate the regulatory effects of iTBS intervention on brain functional activity from the perspective of brain functional connectivity, providing reference and evidence for the clinical application of iTBS.
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