Evidence map›Paper›PMID 40933055›Full record

ReviewFrontiers in neurology2025

Perioperative neurocognitive disorders: a comprehensive review of terminology, clinical implications, and future research directions.

Xuli Ren, Lian Huiqiao, Yuntu Wu, Te Zhang, Peng Chen, Longyun Li, Guoqing Zhao, Fang Wang

4 registry-linked trialsAbstract readReview
In one paragraph

Review in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07533370 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Extended Emergence Trajectory on Post-Anesthesia Care Units Events in Ambulatory Lower-Extremity Orthopedic Surgery: A Randomized Controlled Trial

TypeinterventionalSponsorHarrison Shong-Wen ChowRan2026 to 2027Enrolled300ConditionsPerioperative Care, EEG Power Spectra, Delirium - PostoperativeArmsStandard of Care EEG-Guided Emergence, Extended EEG Emergence Trajectory
NCT07576517 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Perioperative Use of Dexmedetomidine-esketamine Combination and Transcranial Direct Current Stimulation for Prevention of Neurocognitive Complications in Older Patients After Non-cardiac Surgery: a 2×2 Factorial Trial

TypeinterventionalSponsorPeking University First HospitalRan2026 to 2030Enrolled1,160ConditionsOlder Patients, Surgery, Dexmedetomidine, EsketamineArmsDex-Esk, Placebo, Active tDCS, Sham tDCS
NCT07576543 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Long-term Follow-up of Perioperative Dexmedetomidine-esketamine Combination and Transcranial Direct Current Stimulation for Prevention of Neurocognitive Complications in Older Patients After Non-cardiac Surgery

TypeinterventionalSponsorPeking University First HospitalRan2026 to 2031Enrolled1,160ConditionsOlder Patients, Surgery, Dexmedetomidine, EsketamineArmsDex-Esk, Placebo, Active tDCS, Sham tDCS
NCT07736092 narecruitingnot on this mapstarted 2026, after this paper: background citation

Impact of Perioperative Transcranial Photobiomodulation on Delayed Neurocognitive Recovery in Older Patients After Surgery: a Randomized, Double-blind, Pseudo-modulation-controlled Preliminary Clinical Trial

TypeinterventionalSponsorPeking University First HospitalRan2026 to 2027Enrolled130ConditionsOlder Adults, Surgery, Transcranial Photobiomodulation, Delayed Neurocognitive RecoveryArmsTranscranial photobiomodulation therapy, Transcranial pseudo-photobiomodulation
3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Observational
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. PreoperativeFrontiers in bioinformatics · 2026
    Review
  10. Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xuli RenJilin University, Changchun, China.
Lian HuiqiaoJilin University, Changchun, China.
Yuntu WuRehabilitation Department of Mongolian Hospital in Kuleun Banner, Tongliao City, Inner Mongolia Autonomous Region, China.
Te ZhangDepartment of Anesthesiology, The Third Hospital of Jilin University, Changchun, Jilin, China.
Peng ChenDepartment of Anesthesiology, The Third Hospital of Jilin University, Changchun, Jilin, China.
Longyun LiDepartment of Anesthesiology, The Third Hospital of Jilin University, Changchun, Jilin, China.
Guoqing ZhaoJilin University, Changchun, China.
Fang WangSchool of Basic Medicine, Jilin Medical University, Changchun, Jilin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Perioperative neurocognitive disorders (PNDs) encompass a spectrum of cognitive impairments that may affect patients before, during, or after surgical procedures, with significant implications for patient outcomes, and healthcare expenditures. This comprehensive review examines the evolution of PND terminology, clinical manifestations, diagnostic criteria, incidence rates, risk factors, underlying mechanisms, preventive measures, management strategies, and future research directions. The authors emphasize the importance of early diagnosis and intervention to enhance postoperative recovery and underscore the necessity of a multidisciplinary approach to patient care.

Indexed as

cognitive rehabilitationdelirium diagnosisneurocognitive recoveryperioperative neurocognitive disordersperioperative risk factorspostoperative cognitive dysfunctionsurgical outcomes

Identifiers

PMID40933055
PMCPMC12418783

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.