ReviewWorld journal of biological chemistry2025
CD47/SIRPα pathways: Functional diversity and molecular mechanisms.
Review in World journal of biological chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Article
- Cannabidiol Regulates CD47 Expression and Apoptosis in Jurkat Leukemic Cells Dependent upon VDAC-1 Oligomerization.Pharmaceuticals (Basel, Switzerland) · 2026Article
- The SIRP family: from structural diversity and signaling mechanisms to implications in immune-related disease targeted therapeutics.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cellular communication is required for the normal function and maintenance of homeostasis. The extracellular communications are mediated by cell surface receptors, which transmit signals for various cell functions. Cell defense also relies on distinguishing between self and non-self. The integrins belong to the transmembrane receptors family and serve a crucial function in cell-extracellular adhesion and cell-cell signaling. The cell surface integrin-associated protein, or CD47, is an important integrin regulator and performs an array of functions. The CD47 interacts with the signal regulatory protein α (SIRPα) and regulates adhesion, apoptosis, phagocytosis, proliferation, metabolism, activation, hematopoietic stem cell migration, and malignancies. The CD47 expression is increased in tumor cells to escape immune response. The anti-CD47 antibodies have shown promising therapeutic strategies in various clinical trials in the treatment of hematologic and solid tumors. In the current review, we discussed multifunctional roles, molecular mechanisms, and therapeutic strategies of tumors by utilizing CD47/SIRPα interactions.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.