SynthesisFrontiers in physiology2025
Effect of exercise on brain-derived neurotrophic factors in middle-aged and older adults with type 2 diabetes mellitus: a systematic review and meta-analysis.
Synthesis in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Moderate Exercise Mitigates Diabetes-Induced Hippocampal Dysfunction in Aged Rats.International journal of molecular sciences · 2026Article
- Optimizing exercise modalities to enhance brain-derived neurotrophic factor levels in older adults: a Bayesian network and dose-response meta-analysis.Frontiers in physiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Although previous studies have indicated that exercise can improve brain-derived neurotrophic factor (BDNF) levels in middle-aged and older adults with type 2 diabetes mellitus (T2DM), discrepancies remain among the findings. Therefore, this study aims to determine the impact of exercise on BDNF concentrations in middle-aged and older adults with T2DM. Methods: A systematic search was conducted across multiple databases, including PubMed, Embase, EBSCO, Cochrane Library, CNKI, and Web of Science, covering the period from the inception of each database to October 2024. The search process adhered to the PRISMA and PERSiST guidelines. Two independent evaluators were responsible for conducting the search, screening results, extracting data, and assessing study quality. A random-effects model was employed to calculate the standardized mean difference (SMD) and 95% confidence interval (CI). Results: This meta-analysis included 13 studies involving 206 middle-aged and elderly individuals with T2DM. The results showed that exercise effectively increased BDNF levels in middle-aged and elderly individuals with T2DM (SMD = 0.73, 95% CI: 0.07-1.39, Conclusion: Exercise has a significant positive effect on BDNF levels in middle-aged and older adults with T2DM. Chronic exercise and exercise lasting more than 150 min per week have a more significant effect on increasing BDNF levels in middle-aged and older adults with T2DM. In addition, when non-immediate blood sampling methods are used to measure serum BDNF levels after exercise, a significant increase in BDNF concentration is observed. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/#myprospero, identifier CRD42024621098.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.