Evidence map›Paper›PMID 40933484›Full record

ArticleFrontiers in genetics2025

Novel estrogen-related gene variants identified by whole-exome sequencing in pregnancy-associated intrahepatic cholestasis.

Hua Lai, Siming Xin, Jinliang Zhang, Yang Hu, Wenjuan Fan, Hong Wan, Bowen Chen, Yang Zou, Xiaoming Zeng, Xianxian Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hua Lai *Central Laboratory, Jiangxi Maternal and Child Health Hospital, Nanchang, Jiangxi, China.
Siming Xin *Central Laboratory, Jiangxi Maternal and Child Health Hospital, Nanchang, Jiangxi, China.
Jinliang ZhangCentral Laboratory, Jiangxi Maternal and Child Health Hospital, Nanchang, Jiangxi, China.
Yang HuCentral Laboratory, Jiangxi Maternal and Child Health Hospital, Nanchang, Jiangxi, China.
Wenjuan FanCentral Laboratory, Jiangxi Maternal and Child Health Hospital, Nanchang, Jiangxi, China.
Hong WanCentral Laboratory, Jiangxi Maternal and Child Health Hospital, Nanchang, Jiangxi, China.
Bowen ChenCentral Laboratory, Jiangxi Maternal and Child Health Hospital, Nanchang, Jiangxi, China.
Yang ZouCentral Laboratory, Jiangxi Maternal and Child Health Hospital, Nanchang, Jiangxi, China.
Xiaoming ZengCentral Laboratory, Jiangxi Maternal and Child Health Hospital, Nanchang, Jiangxi, China.
Xianxian LiuCentral Laboratory, Jiangxi Maternal and Child Health Hospital, Nanchang, Jiangxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intrahepatic cholestasis of pregnancy (ICP) is associated with an increased risk of adverse fetal outcomes, including fetal morbidity and mortality. It is a complex liver disorder influenced by genetic interactions, estrogen levels, and environmental factors. Although elevated estrogen levels are known to contribute to ICP pathogenesis, the role of genetic variants in estrogen-related genes remains poorly characterized. Accordingly, we conducted whole-exome sequencing (WES) in 249 patients with ICP, focusing on eight key estrogen-related genes (

Indexed as

CYP17A1 geneestrogen-related genesintrahepatic cholestasis of pregnancynovel variantswhole-exome sequencing

Identifiers

PMID40933484
PMCPMC12417162

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.