Evidence map›Paper›PMID 40933642›Full record

ArticleiScience2025

Distribution of glutamate and glutamine in tumor microenvironments of brain metastasis: Insights from biochemical analysis and molecular imaging.

Jun Tang, Yutong Zhao, Liangpeng Chen, Yangyang Liu, Hexin Xie, Zehui Wu, Lu Zhang, Di Fan, Xiaoxia Xu, Lin Ai and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jun TangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Yutong ZhaoBeijing Neurosurgical Institute, Capital Medical University, Beijing 100070, China.
Liangpeng ChenDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Yangyang LiuDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Hexin XieDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Zehui WuBeijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing 100069, China.
Lu ZhangBeijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing 100069, China.
Di FanDepartment of Nuclear Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Xiaoxia XuState Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China.
Lin AiDepartment of Nuclear Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Qian LiuBeijing Neurosurgical Institute, Capital Medical University, Beijing 100070, China.
Hua ZhuState Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China.
Deling LiDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer neuroscience has implicated peritumoral neurons in facilitating breast-to-brain metastasis (BrBM) progression via the N-methyl-D-aspartate receptor (NMDAR), a glutamate (Glu) receptor. The Glu-glutamine (Gln) cycle converts Glu into Gln, forming the combined Glx pool. This study investigated the spatial distribution of phosphorylated GluN2B (pGluN2B), an NMDAR subunit, and Glx in BrBM.

Indexed as

Molecular biologyPathologyRadiation biology

Identifiers

PMID40933642
PMCPMC12419101

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.