SynthesisFrontiers in pediatrics2025
Pediatric massage in conjunction with other traditional Chinese medicine therapies for tic disorder in children: systematic review and network meta-analysis.
Synthesis in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Knowledge, Attitudes, and Practices of Caregivers of Children with Tic Disorders Regarding the Traditional Chinese Medicine Diagnosis and Treatment of the Condition.Journal of multidisciplinary healthcare · 2026Article
- Tuina therapy alleviates neuropathic pain by modulating the CX3CL1/CX3CR1 axis to inhibit degradation of the perineuronal nets.Frontiers in molecular neuroscience · 2026Article
- TPM-like manipulations exerted an antidepressant effect and regulated amino acid metabolism and GHR/IGF-1 pathway in the liver in adolescent female CUMS rats.Frontiers in physiology · 2026Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Pediatric massage (PM) belongs to traditional Chinese medicine treatment (TCM) and is an alternative therapy for tic disorders (TD). This systematic review and network meta-analysis (NMA) was undertaken to evaluate the efficacy and safety of PM, the effectiveness of PM in conjunction with other TCM therapies for TD and to provide an evidence-based foundation for the clinical selection of the TD treatment regimens relating to traditional Chinese medicine. Methods: Eight databases were systematically searched from their inception to June, 2024 for randomized controlled trials (RCTs) of PM and its combination with other TCM therapies for TD. Two researchers screened the studies and extracted the data according to our inclusion criteria, and the bias assessment tool from the Cochrane Handbook was used to evaluate the quality of the included studies. Stata 17.0 software was used to perform NMA, and the efficacy and safety of PM and its combination with other TCM therapies were compared and ranked. Results: A total of 24 RCTs, covering 1,657 children with TD, were included in this NMA. There were 9 intervention measures, including PM, Western medicine (WM), PM + Chinese herbal medicine (CHM), PM + manual acupuncture (MA), PM + auricular acupuncture (AA), PM + Qigong therapy (QT), PM + cupping therapy (CT), PM + scraping therapy (ST), and PM + moxibustion (Mox). PM + CHM may be most effective at improving the total effective rate and decreasing YGTSS motor tics score and YGTSS vocal tics score; PM + MA may have the best performance in reducing the YGTSS total score; and simple PM may be the best at reducing the adverse reaction rate. The GRADE assessment showed that the overall response rate and the total YGTSS score were rated as low or very low quality due to the limitations of the original study, and other measures were rated as moderate quality. Therefore, these results need to be interpreted with caution and validated further. Conclusion: PM and its combination with other TCM therapies are effective and safe interventions for TD in children. More specifically, PM + CHM may be the best choice for improving clinical effectiveness and reducing YGTSS motor tics score and YGTSS vocal tics score, while PM + MA may be the most effective for decreasing YGTSS total score. However, due to the limitations of this study, these conclusions still need to be validated using additional high-quality RCTs. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42024553846, PROSPERO CRD42024553846.
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