ReviewJournal of inflammation research2025
The Role of Inflammatory Biomarkers (IL-1, IL-6, TNF-α, and Alpha-Amylase) in Saliva on Post-Odontectomy Swelling: A Rapid Review.
Review in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Synergistic HA-tooth graft composite promotes rapid alveolar bone healing via IL-6 suppression and OCN enhancement.Journal of oral biology and craniofacial researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Odontectomy is a commonly performed surgical procedure in the oral cavity and has several possible postoperative complications, including swelling. In addition to clinical examination, post-odontectomy swelling can be identified by utilizing saliva samples to analyze inflammatory biomarkers. The purpose of this study was to determine the role of inflammatory biomarkers IL-1, IL-6, TNF-α, and alpha-amylase in saliva on post-odontectomy swelling. Methods: A rapid literature review of clinical studies was conducted using the PRISMA framework. Article searches were performed on six databases (PubMed, ScienceDirect, SpringerLink, Cochrane Library, and EBSCOhost) using boolean operators and hand searching on Google Scholar. Results: Ten articles met the inclusion criteria. A risk of bias assessment was conducted using the JBI critical appraisal tools. Seven articles analyzed alpha-amylase, two articles analyzed TNF-α, and one article analyzed IL-1, IL-6, and TNF-α simultaneously to see the swelling or inflammation that occurs post-odontectomy. These four biomarkers were examined before, immediately after, or up to several days after the procedure. Significant elevations in biomarkers including IL-1, IL-6, TNF-a, and alpha-amylase are seen in the majority of articles. Post-procedure alpha-amylase elevation was observed along with swelling, pain, and fear associated with the odontectomy procedure. Increases in IL-1, IL-6, and TNF-α were observed due to tissue manipulation during the procedure that initiated the production of these proinflammatory cytokines. Conclusion: Inflammatory biomarkers IL-1, IL-6, TNF-α, and alpha-amylase in saliva play a role in post-odontectomy swelling, as their levels increase the intensity of swelling or inflammation also tends to rise. These biomarkers contribute to swelling through mechanisms involving immune cell recruitment, increased vascular permeability, and acute responses to pain and stress. Although it is constrained by the lack of relevant research, this review provides recommendations for further research into the most pertinent salivary biomarkers for identifying post-odontectomy swelling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.