ArticlePsychoradiology2025
Oxytocin modulation of resting-state functional connectivity network topology in individuals with higher autistic traits.
Article in Psychoradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Inflammatory cytokine alterations in autism spectrum disorder and attention-deficit/hyperactivity disorder: a systematic review and network meta-analysis.European child & adolescent psychiatry · 2026Review
- Structuro-Functional Differentiation and Coupling of Gyri and Sulci in the Neonatal Cortex.Human brain mapping · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Altered connectivity patterns in socio-emotional brain networks are characteristic of individuals with autism spectrum disorder. Despite recent research on intranasal oxytocin's modulation effects of network topology in autism, its specific effects on the functional connectivity network topology remain underexplored. Methods: To address this gap, we conducted an exploratory data-driven study employing a dimensional approach using data from a large cohort of 250 neurotypical adult male subjects with either high or low autistic traits and who had administered 24 IU of intranasal oxytocin or placebo in a randomized, controlled, double-blind design. Resting-state functional connectivity data were analyzed using network-based statistical methods and graph theoretical approaches. Results: The findings from treatment × autistic trait group interactions revealed significantly different effects of oxytocin in local (cluster coefficient, efficiency, nodal path length, degree and betweenness centrality) but not global graph metrics in individuals with higher autistic traits compared to those with lower ones, across multiple brain regions. Changes across multiple measures were found in the motor, auditory/language, visual, default mode and socio-emotional processing networks, all of which are influenced in autism spectrum disorder. Conclusion: Overall, findings from this dimensional approach demonstrate that oxytocin particularly targets widespread enhancement of local but not global neural network processing parameters in neurotypical individuals with higher autistic traits. This suggests that intranasal oxytocin may represent a therapeutic option for social, emotional and sensorimotor symptoms in individuals with autism spectrum disorder by modulating local integration within brain regions involved in their regulation.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.