Evidence map›Paper›PMID 40933784›Full record

ReviewTherapeutic advances in psychopharmacology2025

Effect of psilocybin therapy on suicidal ideation, attempts, and deaths in people with psychiatric diagnoses: a systematic review and meta-analysis.

Stanley Wong, Gray Meckling, Nicholas Fabiano, Sanghun Lee, Brett D M Jones, Risa Shorr, Aroldo Dargel, Alan K Davis, Jess G Fiedorowicz, Marco Solmi and 4 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Therapeutic advances in psychopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Psychedelics in treatment-resistant depression: a comprehensive review of mechanisms, clinical evidence, and recommendations.Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2026
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Stanley WongDepartment of Psychiatry, University of Toronto, 250 College Street, Toronto, ON M5T 1R8, Canada.ORCID https://orcid.org/0000-0002-7316-5370
Gray MecklingDepartment of Psychiatry, University of Ottawa, Ottawa, ON, Canada.
Nicholas FabianoDepartment of Psychiatry, University of Ottawa, Ottawa, ON, Canada.
Sanghun LeeDepartment of Psychiatry, University of Toronto, Toronto, ON, Canada.
Brett D M JonesDepartment of Psychiatry, University of Toronto, Toronto, ON, Canada.ORCID https://orcid.org/0000-0003-3248-1059
Risa ShorrLibrary Services, The Ottawa Hospital, Ottawa, ON, Canada.
Aroldo DargelDepartment of Psychiatry, University of Ottawa, Ottawa, ON, Canada.
Alan K DavisCenter for Psychedelic Drug Research and Education, College of Social Work, The Ohio State University, Columbus, OH, USA.
Jess G FiedorowiczDepartment of Psychiatry, University of Ottawa, Ottawa, ON, Canada.
Marco SolmiDepartment of Psychiatry, University of Ottawa, Ottawa, ON, Canada.
Joshua D RosenblatDepartment of Psychiatry, University of Toronto, Toronto, ON, Canada.ORCID https://orcid.org/0000-0002-4773-2191
Benoit H MulsantDepartment of Psychiatry, University of Toronto, Toronto, ON, Canada.
Daniel M BlumbergerDepartment of Psychiatry, University of Toronto, Toronto, ON, Canada.
Muhammad Ishrat HusainDepartment of Psychiatry, University of Toronto, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Suicidal ideation, attempts, and deaths present a major and tragic public health concern. Recent trials of psilocybin therapy (PT) have shown promise in treating treatment-resistant depression and have found a reduction in suicidal ideation. Given the growth of PT research, there is a need to further understand its effect on suicidal ideation, attempts, and deaths. Objective: To assess and synthesize evidence on the effects of PT on suicidal ideation, attempts, and deaths in psychiatric patients. Design: PRISMA-compliant systematic review and meta-analysis. Data source: MEDLINE, EMBASE, Cochrane, and PsychINFO. Method: Databases were searched for randomized controlled trials of PT in adults with psychiatric diagnoses that reported suicide outcomes (ideation, attempts, and deaths). Abstract and full-text screening were conducted, and suicide outcomes were extracted. Meta-analysis was performed with a random effects model to assess changes in suicide outcomes compared to control through the standardized mean difference (SMD). Assessment of heterogeneity, risk of bias, and subgroup analysis was completed. Results: Nine studies were included ( Conclusion: Psilocybin therapy may reduce suicidal ideation in adults with psychiatric diagnoses. Current studies are limited by small sample size, lack of follow-up data, and assessment of blinding. Trial registration: CRD42023445706.

Indexed as

psilocybinpsychedelicssuicidal ideationsuicidesuicide attempts

Identifiers

PMID40933784
PMCPMC12417673

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.