ArticleCell reports2025
Early adipose tissue wasting in a preclinical model of human lung cancer cachexia.
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Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2citing papers in PubMed
–field-weighted citation impact
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Metabolic adaptations of the tumor macroenvironment and their role in cancer progression and survivorship.Genes & development · 2026Review
- Histidine decarboxylase inhibition attenuates cancer-associated muscle wasting.The Journal of experimental medicine · 2025Article
Corrections and comments
- Update of
Authors and funding
23 authors.
Deena B SnokeDepartment of Medicine, University of Vermont College of Medicine, Burlington, VT, USA; University of Vermont Cancer Center, University of Vermont College of Medicine, Burlington, VT, USA.
Jos L van der VeldenDepartment of Pathology and Laboratory Medicine, University of Vermont College of Medicine, Burlington, VT, USA; University of Vermont Cancer Center, University of Vermont College of Medicine, Burlington, VT, USA.
Emma R BellafleurDepartment of Medicine, University of Vermont College of Medicine, Burlington, VT, USA.
Jacob S DearbornDepartment of Surgery, University of Vermont College of Medicine, Burlington, VT, USA; University of Vermont Cancer Center, University of Vermont College of Medicine, Burlington, VT, USA.
Sean M LenahanDepartment of Pathology and Laboratory Medicine, University of Vermont College of Medicine, Burlington, VT, USA; University of Vermont Cancer Center, University of Vermont College of Medicine, Burlington, VT, USA.
Alexandra E BealDepartment of Medicine, University of Vermont College of Medicine, Burlington, VT, USA.
Reem AboushoushaDepartment of Pathology and Laboratory Medicine, University of Vermont College of Medicine, Burlington, VT, USA.
Skyler C J HeiningerDepartment of Medicine, University of Vermont College of Medicine, Burlington, VT, USA.
Jennifer L AtherDepartment of Medicine, University of Vermont College of Medicine, Burlington, VT, USA.
Madeleine M MankDepartment of Medicine, University of Vermont College of Medicine, Burlington, VT, USA.
Hailey SarauskyDepartment of Pathology and Laboratory Medicine, University of Vermont College of Medicine, Burlington, VT, USA; University of Vermont Cancer Center, University of Vermont College of Medicine, Burlington, VT, USA.
Daniel StephensonDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Julie A ReiszDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Angelo D'AlessandroDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Devdoot MajumdarDepartment of Surgery, University of Vermont College of Medicine, Burlington, VT, USA; University of Vermont Cancer Center, University of Vermont College of Medicine, Burlington, VT, USA.
Thomas P AhernDepartment of Surgery, University of Vermont College of Medicine, Burlington, VT, USA; University of Vermont Cancer Center, University of Vermont College of Medicine, Burlington, VT, USA.
Kaiwen XuDepartment of Computer Science, Vanderbilt University and Vanderbilt University Medical Center, Nashville, TN, USA.
Kim L SandlerDepartment of Radiology, Vanderbilt University and Vanderbilt University Medical Center, Nashville, TN, USA.
Bennett A LandmanDepartment of Computer Science, Vanderbilt University and Vanderbilt University Medical Center, Nashville, TN, USA; Department of Biomedical Engineering, Vanderbilt University and Vanderbilt University Medical Center, Nashville, TN, USA; Department of Radiology, Vanderbilt University and Vanderbilt University Medical Center, Nashville, TN, USA.
Yvonne M W Janssen-HeiningerDepartment of Pathology and Laboratory Medicine, University of Vermont College of Medicine, Burlington, VT, USA; University of Vermont Cancer Center, University of Vermont College of Medicine, Burlington, VT, USA.
Matthew E PoynterDepartment of Medicine, University of Vermont College of Medicine, Burlington, VT, USA.
David J SewardDepartment of Pathology and Laboratory Medicine, University of Vermont College of Medicine, Burlington, VT, USA; University of Vermont Cancer Center, University of Vermont College of Medicine, Burlington, VT, USA.
Michael J TothDepartment of Medicine, University of Vermont College of Medicine, Burlington, VT, USA; University of Vermont Cancer Center, University of Vermont College of Medicine, Burlington, VT, USA. Electronic address: michael.toth@med.uvm.edu.
Funding
University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0MPilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Joyce Lee · 2010 to 2026
$20.3MNational Metabolomics Data Repository - nextgen Metabolomics WorkbenchU2CDK119886 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUBRAMANIAM, SHANKAR · 2018 to 2021
$12.7MMichigan Mouse Metabolic Phenotyping CenterU2CDK110768 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELIAS, CAROL FUZETI · 2016 to 2021
$6.2MMultidisciplinary Training in Lung BiologyT32HL076122 · NHLBI · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI IRVIN, CHARLES G, POYNTER, MATTHEW E · 2004 to 2023
$6.1MNovel Integrative Approach for the Early Detection of Lung Cancer using Repeated MeasuresR01CA253923 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LANDMAN, BENNETT A., MALDONADO, FABIEN · 2021 to 2025
$3.4MBiomedical Data Commons Workbench (BDCW)OT2OD030544 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUBRAMANIAM, SHANKAR · 2020 to 2024
$3.2MGlutaredoxin, Glutathione Metabolism and Lung CancerR01CA273238 · NCI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Yvonne M. W. Janssen-Heininger · 2023 to 2026
$2.1MSkeletal Muscle Atrophy and Dysfunction in Human CancerR01AR065826 · NIAMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI TOTH, MICHAEL J · 2016 to 2021
$2.1MDevelopment of a clinically relevant mouse model of lung cancer cachexia to study pathoetiology and therapeutic strategiesR21CA283492 · NCI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI TOTH, MICHAEL J · 2023 to 2024
$392kSTK11 loss of function and anti-PD-1 therapy resistance in KRAS-driven lung adenocarcinomaR21CA280266 · NCI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI SEWARD, DAVID JOSEPH · 2023 to 2024
$392kNCI NIH HHS P30 CA046934NCI NIH HHS R01 CA253923NCI NIH HHS R01 CA273238NCI NIH HHS R21 CA280266NCI NIH HHS R21 CA283492NHLBI NIH HHS T32 HL076122NIAMS NIH HHS R01 AR065826NIDDK NIH HHS P30 DK089503NIDDK NIH HHS U2C DK110768NIDDK NIH HHS U2C DK119886NIH HHS OT2 OD030544
Abstract
Cancer cachexia (CC), a syndrome of skeletal muscle and adipose wasting, reduces responsiveness to therapies and increases mortality. There are no approved treatments for CC, which may relate to discordance between preclinical models and human CC. To address the need for clinically relevant models of lung CC, we generated inducible, lung epithelial cell-specific Kras
Indexed as
Adipose TissueCachexiaLung NeoplasmsAdipocytesAnimalsDisease Models, AnimalFemaleHumansLipolysisMaleMiceProto-Oncogene Proteins p21(ras)Proto-Oncogene Proteins p21(ras)CP: CancerCP: Metabolisminflammationlipolysislung neoplasmsorganoidsskeletal muscle
Identifiers
What Socratic holds
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LicenceCC BY-NC
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.