Evidence map›Paper›PMID 40934670›Full record

ArticleEnvironment international2025

Cardiac electrophysiological responses to traffic pollution in adults with or without chronic cardiopulmonary diseases.

Xin Meng, Yan Lin, Jicheng Gong, Peter Collins, Sabine Ernst, Wu Chen, Meilin Yan, Junfeng Jim Zhang, Kian Fan Chung

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xin MengSKL-ESPC & SEPKL-AERM, College of Environmental Sciences and Engineering, and Center for Environment and Health, Peking University, Beijing, China.
Yan LinNicholas School of the Environment & Duke Global Health Institute, Duke University, Durham, NC, USA.
Jicheng GongSKL-ESPC & SEPKL-AERM, College of Environmental Sciences and Engineering, and Center for Environment and Health, Peking University, Beijing, China. Electronic address: jicheng.gong@pku.edu.cn.
Peter CollinsNational Heart & Lung Institute, Imperial College London & Royal Brompton & Harefield Hospital, London, UK.
Sabine ErnstNational Heart & Lung Institute, Imperial College London & Royal Brompton & Harefield Hospital, London, UK.
Wu ChenSKL-ESPC & SEPKL-AERM, College of Environmental Sciences and Engineering, and Center for Environment and Health, Peking University, Beijing, China; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Meilin YanDepartment of Environmental Science and Engineering, School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing, China.
Junfeng Jim ZhangNicholas School of the Environment & Duke Global Health Institute, Duke University, Durham, NC, USA.
Kian Fan ChungNational Heart & Lung Institute, Imperial College London & Royal Brompton & Harefield Hospital, London, UK. Electronic address: f.chung@imperial.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTraffic pollution exposure has been associated with adverse cardiovascular outcomes, but determinants of individual susceptibility remain unclear. To explore whether disease status modifies traffic-related cardiac responses and to examine the cardioprotective role of nitro linoleic acids.

methodsIn a crossover study, 39 chronic obstructive pulmonary disease (COPD) patients, 38 ischemic heart disease (IHD) patients, and 39 healthy participants walked for two hours on traffic-congested Oxford Street and in traffic-free Hyde Park, in random order, on separate days. Cardiac electrical activity, including heart rate, heart rate variability (HRV), QT interval, and ST-segment changes, was continuously monitored for 24 h. At 24 h following the walk, a urine void was collected and analyzed for nitro linoleic acid NO

resultsIn reference to walking in the park, participants following the street walk exhibited adverse cardiac changes, including increased heart rate, decreased HRV, shortened QT interval, and elevated ST-segment, with larger changes in some parameters observed in COPD participants, though between-group differences were not statistically significant. Among COPD participants, the cardiac effects were more pronounced in those who did not use inhaler medications than in those who used them. NO

conclusionsAlthough between-group comparisons were not statistically significant, COPD patients showed numerically larger electrophysiological changes and reductions in NO

Indexed as

Air PollutantsHeartMyocardial IschemiaPulmonary Disease, Chronic ObstructiveTraffic-Related PollutionVehicle EmissionsAdultAgedCross-Over StudiesFemaleHeart RateHumansMaleMiddle AgedAir PollutantsVehicle EmissionsCardiac effectsChronic obstructive pulmonary diseaseNitro linoleic acidsSusceptibilityTraffic pollution

Identifiers

PMID40934670
PMCPMC12450113

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.