ArticleThe journal of nutrition, health & aging2025
Global, regional, and national burden of autoimmune disease in older adults (≥60 years) from 1990 to 2021: Results from the Global Burden of Disease Study 2021.
Article in The journal of nutrition, health & aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comorbid autoimmune disease in stiff-person syndrome spectrum disorder: a systematic review and meta-analysis.Journal of neurology · 2026Pooled it
- Nanoparticles for autoimmune diseases: advancing diagnostics and therapeutic solutions.Acta pharmacologica Sinica · 2026Review
- Bioinformatics analysis reveals shared gene signatures and molecular mechanisms between periodontitis and rheumatoid arthritis in the context of aging.Acta odontologica Scandinavica · 2026Article
- Murine and Humanized Mouse Models in Autoimmune Disease Research and Therapeutics Development.Biology · 2026Review
- The problem with one-size-fits-all medicine: Biological sex and the aging immune system.PLoS biology · 2026Article
- Oxidative-Stress-Associated Molecular Signatures in Immune-Mediated Diseases: A Systematic Review Integrating Machine Learning and Systems Biology Approaches.Antioxidants (Basel, Switzerland) · 2026Review
- Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo analyze and model the global, regional, and national burden of autoimmune diseases (ADs) among older adults (≥60 years) from 1990 to 2021.
methodsData were extracted from the Global Burden of Disease (GBD) 2021 data for 204 countries and territories. Age-standardized incidence, prevalence, mortality, and disability-adjusted life years (DALY) rates were calculated with 95% uncertainty intervals (UIs). Temporal trends were assessed using estimated annual percentage change (EAPC, with 95% Confidence Intervals [95% CI]). Future trends to 2035 were projected using a log-linear age-period-cohort model.
resultsIn 2021, the Americas and Europe had the highest burden of ADs in older adults. From 1990 to 2021, age-standardized incidence and prevalence rates increased notably for rheumatoid arthritis (EAPC for incidence rate: 0.75, 0.70-0.79; for prevalence rate: 0.54, 0.50-0.58) and type 1 diabetes (incidence rate: 0.78, 0.70-0.86; prevalence rate:0.84, 0.81-0.88). Psoriasis showed smaller but consistent increases, while inflammatory bowel disease rose only modestly, and multiple sclerosis remained relatively stable. Projections suggest continued increases in age-standardized incidence and prevalence rates for most ADs through 2035.
conclusionsThe burden of ADs among older adults is rising globally, with particularly high rates in the Americas and Europe. These findings highlight the urgent need for strategic resource allocation and targeted prevention and management strategies to address ADs in aging populations.
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