Evidence map›Paper›PMID 40935349›Full record

ArticleFree radical biology & medicine2025

Iron-oxide nanoparticles selectively enhance the toxicity of pharmacological ascorbate through hydrogen peroxide-dependent DNA damage in non-small cell lung cancer (NSCLC).

Mekhla Singhania, Sei Sho, Melissa A Fath, Adriana Sanchez, Casey F Pulliam, Bryan G Allen, Garry R Buettner, Prabhat C Goswami, Maria Spies, Michael S Petronek and 1 more

Abstract read
In one paragraph

Article in Free radical biology & medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mekhla SinghaniaDepartment of Radiation Oncology, Division of Free Radical and Radiation Biology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA.
Sei ShoDepartment of Radiation Oncology, Division of Free Radical and Radiation Biology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA.
Melissa A FathDepartment of Radiation Oncology, Division of Free Radical and Radiation Biology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA.
Adriana SanchezDepartment of Radiation Oncology, Division of Free Radical and Radiation Biology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA.
Casey F PulliamDepartment of Radiation Oncology, Division of Free Radical and Radiation Biology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA.
Bryan G AllenDepartment of Radiation Oncology, Division of Free Radical and Radiation Biology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA.
Garry R BuettnerDepartment of Radiation Oncology, Division of Free Radical and Radiation Biology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA.
Prabhat C GoswamiDepartment of Radiation Oncology, Division of Free Radical and Radiation Biology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA.
Maria SpiesDepartment of Radiation Oncology, Division of Free Radical and Radiation Biology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA.
Michael S PetronekDepartment of Radiation Oncology, Division of Free Radical and Radiation Biology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA. Electronic address: michael-petronek@uiowa.edu.
Douglas R SpitzDepartment of Radiation Oncology, Division of Free Radical and Radiation Biology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA. Electronic address: douglas-spitz@uiowa.edu.

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Jon C.D. Houtman · 2000 to 2026
$70.0M
Project 3: MRI Imaging of Redox Active Fe Predicts GBM Responses to Pharmacological AscorbateP01CA217797 · NCI · UNIVERSITY OF IOWA · PI BUATTI, JOHN M · 2018 to 2022
$9.6M
Project 4: Mechanistic Basics of FLASH Effect: Role of O2P01CA244091 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI LIMOLI, CHARLES · 2020 to 2024
$9.6M
TRAINING PROGRAM IN FREE RADICAL AND RADIATION BIOLOGYT32CA078586 · NCI · UNIVERSITY OF IOWA · PI SPITZ, DOUGLAS ROBERT · 1999 to 2024
$5.7M
Repurposing redox active agents for exploiting differences in cancer cell metabolism for improving cancer therapyR50CA243693 · NCI · UNIVERSITY OF IOWA · PI FATH, MELISSA ANN · 2019 to 2023
$776k
Evaluation of Orthogonally Oriented Electromagnetic Fields to Stabilize ROS, Induce DNA damage and Improve Survival in Non-Small Cell Lung CancerR21CA256301 · NCI · UNIVERSITY OF IOWA · PI SHEFFIELD, VAL C., SPITZ, DOUGLAS ROBERT · 2021 to 2022
$394k
NCI NIH HHS P01 CA217797NCI NIH HHS P01 CA244091NCI NIH HHS P30 CA086862NCI NIH HHS R21 CA256301NCI NIH HHS R50 CA243693NCI NIH HHS T32 CA078586
6 · The paper itself

Abstract

Pharmacological ascorbate (IV delivery, to plasma levels ≈ 15-20 mM) has been shown to be selectively toxic to cancer vs. normal cells as well as inducing radio-chemo-sensitization in non-small cell lung cancer (NSCLC) via increased generation of hydrogen peroxide (H

Indexed as

Ascorbic AcidCarcinoma, Non-Small-Cell LungDNA DamageFerric CompoundsFerrosoferric OxideHydrogen PeroxideLung NeoplasmsNanoparticlesA549 CellsCatalaseCell Line, TumorHumansOxidation-ReductionAscorbic AcidCatalaseFerric Compoundsferric oxideFerrosoferric OxideHydrogen PeroxideAscorbateDNA damageFerahemeFerrous ironFerumoxytolHydrogen peroxideIronNanoparticlesNon-small cell lung cancerVitamin C

Identifiers

PMID40935349
PMCPMC12519564

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.