Evidence map›Paper›PMID 40935731›Full record

ReviewSeminars in nephrology2025

When the Heart Hurts the Kidneys: From Flow to Translational Future.

Kevin G Burfeind, Daiki Aomura, Jessica F Hebert, Michael P Hutchens

Abstract readReview
In one paragraph

Review in Seminars in nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kevin G BurfeindDepartment of Anesthesiology & Perioperative Medicine, Oregon Health and Science University, Portland, OR.
Daiki AomuraDepartment of Anesthesiology & Perioperative Medicine, Oregon Health and Science University, Portland, OR.
Jessica F HebertDivison of Nephrology & Hypertension, Oregon Health and Science University, Portland, OR.
Michael P HutchensDepartment of Anesthesiology & Perioperative Medicine, Oregon Health and Science University, Portland, OR; Divison of Nephrology & Hypertension, Oregon Health and Science University, Portland, OR; Operative Care Division, Portland Veterans Administration Medical Center, Portland, OR. Electronic address: hutchenm@ohsu.edu.

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
Oregon Clinical and Translational Research Institute KL2 SupplementKL2TR002370 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Catherine Lee Hough · 2017 to 2026
$10.1M
BLRD VA I01 BX004288NCATS NIH HHS KL2 TR002370NCATS NIH HHS UL1 TR001414
6 · The paper itself

Abstract

Acute cardiorenal syndrome (cardiorenal syndrome type 1, CRS1) is a common complication of the most common cause of death, cardiovascular disease, and therefore is of considerable importance. Foundational research over the last 100 years detailed the elegant interplay between cardiovascular function and tubuloglomerular feedback that underpins the classic description of CRS1. However, as research into acute kidney injury has elucidated important modifying factors in sex difference, immune regulation, and proximal tubule function, these areas are ripe for investigation in CRS1. Here, we briefly review the nascent state of knowledge regarding CRS1 in women and sex differences, immune contributions, and proximal tubule transport function.

Indexed as

Cardio-Renal SyndromeKidney Tubules, ProximalAcute Kidney InjuryAnimalsFemaleHumansMaleSex CharacteristicsSex FactorsAcute cardiorenal syndromeacute kidney injuryAKIheart failureimmune responseperipartum cardiomyopathypreeclampsiatransport biology

Identifiers

PMID40935731
PMCPMC12431675

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.