ArticleNature communications2025
Social exposome and brain health outcomes of dementia across Latin America.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Alzheimer neuropathological change, α-synuclein and transactive response DNA-binding protein of 43 kDa expression in children and young adult brains from forensic autopsies: Value for early measurement of abnormal protein expression prevalence in neurodegenerative diseases.Journal of neuropathology and experimental neurology · 2026Article
- Genetic-exposome interactions and aging clocks in dementia: the ReDLat2 initiative.Nature medicine · 2026Article
- Emerging directions in tauopathy research.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Social vulnerability shapes deep clinical phenotypes and brain health in aging and dementia across Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- The exposome of brain aging across 34 countries.Nature medicine · 2026Article
- Exposure to negative physical and social factors accelerates brain aging.Nature medicine · 2026Article
- Contextualizing Blood-Based Biomarkers for Dementia Globally.Journal of neurochemistry · 2026Review
- A harmonized framework for studying exceptional cognitive aging in Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- The landscape of dementia research, diagnosis, treatment, and care in Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Childhood adversities and the exposome in dementia risk and brain health.Current opinion in psychiatry · 2026Review
- From cradle to cortex: An exposome- and equity-centered perspective of neurocognitive aging and dementia risk in the era of climate change.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Blood-based AT(N) biomarkers for Alzheimer's disease and frontotemporal lobar degeneration in Latin America.Nature aging · 2026Article
- Expotype-phenotype resilience and multimodal aging clocks.Clinical and translational medicine · 2026Article
- Article
- Extraordinary abilities, creativity, and love, in the path of dementia: a perspective article on the Walking the Talk for Dementia 2025 initiative.Frontiers in dementia · 2026Article
- Computational whole-body-exposome models for global precision brain health.Nature communications · 2025Article
- Dementia prevention requires moving beyond individual choice: the costs of effort and time intersect with social determinants of health.Neuroscience · 2025Review
- Oculomics meets exposomics: a roadmap for applying multi-modal ocular biomarkers in precision environmental health research.Exposome · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
36 authors.
Funding
Abstract
A multidimensional social exposome (MSE)-the combined lifespan measures of education, food insecurity, financial status, access to healthcare, childhood experiences, and more-may shape dementia risk and brain health over the lifespan, particularly in underserved regions like Latin America. However, the MSE effects on brain health and dementia are unknown. We evaluated 2211 individuals (controls, Alzheimer's disease, and frontotemporal lobar degeneration) from a non-representative sample across six Latin American countries. Adverse exposomes associate with poorer cognition in healthy aging. In dementia, more complex exposomes correlate with lower cognitive and functional performance, higher neuropsychiatric symptoms, and brain structural and connectivity alterations in frontal-temporal-limbic and cerebellar regions. Food insecurity, financial resources, subjective socioeconomic status, and access to healthcare emerge as critical predictors. Cumulative exposome measures surpass isolated factors in predicting clinical-cognitive profiles. Multiple sensitivity analyses confirm our results. Findings highlight the need for personalized approaches integrating MSE across the lifespan, emphasizing prevention and interventions targeting social disparities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.