SynthesisPeerJ2025
Pregnancy-associated plasma protein A in maternal serum for predicting early gestational diabetes mellitus: a systematic review and meta-analysis.
Synthesis in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study assessed the effectiveness of pregnancy-associated plasma protein A (PAPP-A) in maternal serum in predicting gestational diabetes mellitus (GDM) in different geographical regions. Methods: PubMed, Web of Science, EMBASE, and Cochrane Library databases were searched for articles assessing the diagnostic utility of PAPP-A for GDM up to December 3, 2024. Two independent researchers screened the literature. Study quality was appraised using the QUADAS-2 instrument and RevMan 5.4 software. Stata 15.1 software was leveraged to calculate the combined sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and heterogeneity. The summary receiver operating characteristic curve was plotted to calculate the area under the curve (AUC). Subgroup analysis was also conducted to determine the source of heterogeneity. Results: This study included eight cohort studies, one cross-sectional study, and three case-control studies. A total of 25,183 participants were involved, including 5,993 GDM patients and 19,190 non-GDM patients. Deek's test suggested no notable publication bias ( Conclusions: PAPP-A has a certain diagnostic value for GDM and is helpful for more accurately identifying GDM and reducing the risk of related chronic diseases. Future articles with larger sample sizes and across multiple centers are warranted to explore the combined application of PAPP-A with other biomarkers. This approach may enhance the accuracy of GDM diagnosis. Registry number: PROSPERO (CRD42024617462).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.