SynthesisFrontiers in immunology2025
Natural antidepressants in neuroimmunomodulation: molecular mechanisms, action targets, and therapeutic potential.
Synthesis in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Bergamot Essential Oil Beverage: Preparation, Formulation Optimization, and Preliminary Evaluation of Antidepressant-like Effects in Mice Induced by Chronic Corticosterone Treatment.Foods (Basel, Switzerland) · 2026Article
- Review
- The interplay between inflammation and oxidative stress in depression: pathogenic mechanisms and treatment approaches.Molecular biology reports · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depression is a major global public health issue, yet key bottlenecks remain in understanding its pathophysiological mechanisms, which significantly hinder breakthroughs in precision treatment strategies. Recent studies have highlighted the neuroimmune system as a primary pathogenic contributor to the onset and progression of depression. Meanwhile, natural products, characterized by multi-component synergy, multi-target activity, and multi-pathway regulation, have shown significant potential in regulating neuroimmunity. However, a systematic review of the role of neuroimmunity in the pathological process of depression and the therapeutic effects of natural products is still lacking. This review aims to comprehensively elucidate the core role of neuroimmunity in the pathological mechanisms of depression through literature analysis, explore in depth the molecular mechanisms and targets involved in natural product interventions, and critically evaluate the limitations and current challenges in clinical translation. Ultimately, this review provides a solid theoretical foundation and guidance for future research and the development of precision antidepressant therapies based on natural products.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.