Evidence map›Paper›PMID 40936920›Full record

ArticleFrontiers in immunology2025

Role of the CX3CL1/CX3CR1 axis in iron metabolism and immune regulation during acute

Sirlaine Pio, Tatiana Prata Menezes, Vitória Louise, Guilherme de Paula Costa, Daniel Malta Oliveira, Natiele Carlos, Silvia Paula-Gomes, Luiza Oliveira Perucci, André Talvani

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sirlaine PioLaboratory of Immunobiology of Inflammation, Department of Biological Science, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, Brazil.
Tatiana Prata MenezesLaboratory of Immunobiology of Inflammation, Department of Biological Science, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, Brazil.
Vitória LouiseGraduate Program in Health Sciences - Infectiology and Tropical Medicine, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Guilherme de Paula CostaLaboratory of Immunobiology of Inflammation, Department of Biological Science, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, Brazil.
Daniel Malta OliveiraLaboratory of Immunobiology of Inflammation, Department of Biological Science, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, Brazil.
Natiele CarlosLaboratory of Immunobiology of Inflammation, Department of Biological Science, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, Brazil.
Silvia Paula-GomesLaboratory of Biochemistry and Molecular Biology, Department of Biological Science, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, Brazil.
Luiza Oliveira PerucciSchool of Medicine, University of California, San Diego, San Diego, CA, United States.
André TalvaniLaboratory of Immunobiology of Inflammation, Department of Biological Science, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, Brazil.

Funding

TRAINING IN REPRODUCTIVE SCIENCEST32HD007203 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PAMELA L MELLON · 1988 to 2026
$4.8M
NICHD NIH HHS T32 HD007203
6 · The paper itself

Abstract

Introduction: During Methods: Male C57BL/6 mice were infected with 10 Results: Treatment reduced spleen mass and cardiac levels of CCL2 and IL-15, with an increase of IL-4. Conversely, in skeletal muscle, TNF, IL-6, and IL-10 increased, while IL-15 decreased. Liver tissue showed reduced IL-15, IL-6, and IL-1β levels, alongside lowered plasma hepcidin and ferritin concentrations. Discussion: These findings highlight CX3CL1's site-specific role in modulating inflammation and iron metabolism during acute

Indexed as

Chagas DiseaseChemokine CX3CL1CX3C Chemokine Receptor 1IronTrypanosoma cruziAcute DiseaseAnimalsCytokinesDisease Models, AnimalMaleMiceMice, Inbred C57BLSignal TransductionChemokine CX3CL1CX3C Chemokine Receptor 1Cx3cl1 protein, mouseCx3cr1 protein, mouseCytokinesIroncardiac diseaseCX3CL1CX3CR1inflammationTrypanosoma cruzi

Identifiers

PMID40936920
PMCPMC12420253

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.