ReviewFrontiers in immunology2025
Personalized immunization to optimize vaccine immunogenicity: exploring the multidimensional effects of host intrinsic factors, external intervention strategies, and the external environment.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Targeting ARF6-SUCNR1 Axis: Antisense Oligonucleotide Adjuvants for Neutrophil Immunometabolism.International journal of molecular sciences · 2026Review
- Risk factors for adverse events following rabies vaccination: a multivariate analysis of real-world data.Frontiers in public health · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vaccines are a fundamental tool in the prevention and control of infectious diseases; however, significant individual variability in immunogenicity exists. This variability is not solely attributable to vaccine characteristics but is also influenced by a range of factors. This review systematically examines the key factors influencing vaccine immunogenicity, with particular emphasis on host-intrinsic factors (e.g., metabolic status, genetic background), personalized external interventions, such as optimized vaccine delivery techniques (e.g., aspiration-based skin delivery) and immunomodulatory adjuvant therapies (e.g., acupuncture, moxibustion, and near-infrared light therapy), as well as environmental exposures and immune memory. By examining the mechanisms and recent research advancements associated with these factors, this paper seeks to provide a foundation for the development of personalized vaccination strategies to address future public health challenges.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.