ArticleFrontiers in neurology2025
Thirty minutes of daily artificial gravity does not mitigate head down tilt induced brain activity changes during cognitive task performance.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Studies have shown that microgravity results in high dual task costs when crewmembers perform cognitive-motor dual tasking. Head-down tilt bedrest (HDBR) has been widely used as a spaceflight analog environment, recreating some of the sensorimotor and cognitive changes, headward fluid shifts, and unloading of bones and muscles. Here, we examined whether artificial gravity (AG) mitigates changes in cognitive performance and associated brain activity that occur in the HDBR environment. Methods: We tested one group of participants ( Results: Brain activation patterns associated with these two tasks changed with HDBR, but there was no difference between the AG and control groups. Compensatory brain-behavioral change-change correlations were observed, where those who increased activation the most had the least decrease in motor tapping accuracy from pre-HDBR to late-HDBR. Discussion: These results suggest that AG does not reduce the need for compensatory brain responses that occur with HDBR, but longer duration and/or more optimal AG phasing may be required.
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