Evidence map›Paper›PMID 40937333›Full record

ArticleClinical kidney journal2025

Effect of dialysate bicarbonate on calciprotein particle crystallization time (T50) in hemodialysis patients-the D-Bic study.

Jennifer Machacek, Peter S Neufeld, Andreas Pasch, Martina Gaggl, Maria C Haller, Edward R Smith, Daniel Cejka

Abstract read
In one paragraph

Article in Clinical kidney journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jennifer MachacekDepartment of Medicine III - Nephrology, Hypertension, Transplantation, Rheumatology, Geriatrics, Ordensklinikum Linz - Elisabethinen Hospital, Linz, Austria.
Peter S NeufeldDepartment of Medicine III - Nephrology, Hypertension, Transplantation, Rheumatology, Geriatrics, Ordensklinikum Linz - Elisabethinen Hospital, Linz, Austria.
Andreas PaschInstitute for Physiology and Pathophysiology, Johannes Kepler University Linz, Austria.ORCID https://orcid.org/0000-0002-7439-0748
Martina GagglCenter for Public Health, Public Health Nutrition, Medical University Vienna, Vienna, Austria.ORCID https://orcid.org/0000-0003-3422-2245
Maria C HallerDepartment of Medicine III - Nephrology, Hypertension, Transplantation, Rheumatology, Geriatrics, Ordensklinikum Linz - Elisabethinen Hospital, Linz, Austria.
Edward R SmithSEHA Kidney Care (SKC)  Abu Dhabi, UAE.
Daniel CejkaDepartment of Medicine III - Nephrology, Hypertension, Transplantation, Rheumatology, Geriatrics, Ordensklinikum Linz - Elisabethinen Hospital, Linz, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Short calciprotein crystallization time (low T50) is directly associated with an increased risk of cardiovascular events and mortality. Here, we investigated whether increases in dialysate bicarbonate concentrations increase T50 times in dialysis patients. Methods: In a prospective, single-center, single-arm, interventional trial in hemodialysis patients ( Results: Twenty-four patients completed the study per protocol. T50 time increased significantly from 246 ± 77 to 282 ± 81 min from the D-Bic 27 to the D-Bic 37 phase ( Conclusions: Raising dialysate bicarbonate resulted in a significant increase in T50 time and a reduction of CPP-2 levels.

Indexed as

bicarbonatecalcification propensitycalciprotein particledialysisT50

Identifiers

PMID40937333
PMCPMC12421725

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.