Evidence map›Paper›PMID 40937500›Full record

ArticleNeurogastroenterology and motility2025

Impact of Ammonia Exposure on the Enteric Nervous System in the Ileum of Pigs From Birth.

Valentina Rafaela Herrera Millar, Mirko Sergio, Katarzyna Palus, Giorgio Mirra, Chiara Cialini, Margherita Pallaoro, Lucia Aidos, Laura Mangiavini, Chiara Bazzocchi, Eleonora Buoio and 3 more

Abstract read
In one paragraph

Article in Neurogastroenterology and motility, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Valentina Rafaela Herrera MillarDepartment of Biomedical Sciences for Health, University of Milan, Milan, Italy.ORCID https://orcid.org/0000-0002-6855-9279
Mirko SergioDepartment of Veterinary Medicine and Animal Science, University of Milan, Lodi, Italy.ORCID https://orcid.org/0009-0000-3954-2657
Katarzyna PalusDepartment of Clinical Physiology, University of Warmia and Mazury, Olsztyn, Poland.ORCID https://orcid.org/0000-0002-7593-9552
Giorgio MirraDepartment of Biomedical Sciences for Health, University of Milan, Milan, Italy.ORCID https://orcid.org/0009-0003-7850-8904
Chiara CialiniDepartment of Veterinary Medicine and Animal Science, University of Milan, Lodi, Italy.ORCID https://orcid.org/0009-0007-5647-7894
Margherita PallaoroDepartment of Biomedical Sciences for Health, University of Milan, Milan, Italy.ORCID https://orcid.org/0000-0002-8292-4543
Lucia AidosDepartment of Veterinary Medicine and Animal Science, University of Milan, Lodi, Italy.ORCID https://orcid.org/0000-0002-6419-9122
Laura MangiaviniDepartment of Biomedical Sciences for Health, University of Milan, Milan, Italy.ORCID https://orcid.org/0000-0003-1892-1249
Chiara BazzocchiDepartment of Veterinary Medicine and Animal Science, University of Milan, Lodi, Italy.ORCID https://orcid.org/0000-0001-6744-2178
Eleonora BuoioDepartment of Veterinary Medicine and Animal Science, University of Milan, Lodi, Italy.ORCID https://orcid.org/0000-0002-5847-4327
Annamaria CostaDepartment of Veterinary Medicine and Animal Science, University of Milan, Lodi, Italy.ORCID https://orcid.org/0000-0003-1038-6886
Silvia Clotilde Bianca ModinaDepartment of Veterinary Medicine and Animal Science, University of Milan, Lodi, Italy.ORCID https://orcid.org/0000-0002-2780-5971
Alessia Di GiancamilloDepartment of Biomedical Sciences for Health, University of Milan, Milan, Italy.ORCID https://orcid.org/0000-0003-1674-3020

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBest Available Techniques have been introduced in the EU to counteract pollution related to intensive farming and its effect on the health of animals and workers. It is known that high levels of ammonia (NH

methodsTwo farms with different manure removal systems were considered (Recirculation and Vacuum), where two different NH KEY

resultsNo differences were found in Peyer's patches morphology. The mucus layer thickness was higher, and the acidic mucins were lower in the RS animals. Results revealed changes in the number and area of neuronal and glial cells, and an upregulation of choline acetyltransferase (ChAT) and galanin (GAL) genes was observed. CONCLUSIONS AND INFERENCES: The alteration of the Enteric Nervous System (ENS) highlighted a connection between high levels of environmental NH

Indexed as

AmmoniaEnteric Nervous SystemIleumAnimalsSwineAmmoniaammoniaENSgutneuronal plasticitypig

Identifiers

PMID40937500
PMCPMC12534584

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.