ReviewComprehensive physiology2025
Estrogen Modulation of B Cell Immunity: Implications for HIV Control and Therapeutic Strategies.
Review in Comprehensive physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- The HIV Reservoir and Immune Landscape Across the Life Course of Women: Implications for Cure Strategies.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026Review
- Dual T-cell exhaustion and hyperactivation profiles identify patients with advanced HIV at high risk for fungal co-infections.BMC infectious diseases · 2026Article
- Epidemiology, Risk Factors, and Management of Pregnancy-Related Chronic Back Pain.Current pain and headache reports · 2026Review
- Article
- Estrogen Modulation of B Cell Immunity: Implications for HIV Control and Therapeutic Strategies.Comprehensive physiology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Biological sex profoundly impacts HIV acquisition, disease progression, and persistence. Beyond genetic differences, sex hormones such as estrogen play multifaceted roles in shaping immune responses to HIV. However, the precise effects of estrogen and other sex hormones on the various components of the immune system, and their implications for HIV progression and persistence, remain poorly understood. Addressing these gaps is essential for developing strategies to improve the management of chronic HIV, especially in post-menopausal cisgender women and transgender women. B cells are crucial for HIV control, primarily through the production of anti-HIV antibodies. Emerging evidence suggests that estrogen exerts significant, yet underappreciated, effects on B cell function. However, the interactions between estrogen and B cells during HIV remain poorly characterized. This review explores current insights into the estrogen-B cell axis, emphasizing its role in modulating immune responses critical to HIV. Specifically, it examines estrogen's effects on B cell activation, antibody production, and antibody functionality, all of which can influence HIV control and disease progression. We also highlight key research gaps, including the impact of differential estrogen levels on immune-mediated HIV control and the potential of estrogen modulators to enhance B cell-driven immunity during HIV.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.