Evidence map›Paper›PMID 40937694›Full record

ArticleDevelopment (Cambridge, England)2025

Nascent dendrite branches initiated by a localized burst of Spire-dependent actin polymerization.

Deirdre Hatton, Claire Marquilly, Caitlin Hanrahan, Tiago Ferreira, Yimiao Ou, Lauren Cinq-Mars, Will Silkworth, Hannah M Bailey, Margot E Quinlan, Donald J van Meyel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Development (Cambridge, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Deirdre HattonCentre for Research in Neuroscience, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, H3G 1A4Canada.
Claire MarquillyCentre for Research in Neuroscience, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, H3G 1A4Canada.
Caitlin HanrahanCentre for Research in Neuroscience, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, H3G 1A4Canada.
Tiago FerreiraCentre for Research in Neuroscience, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, H3G 1A4Canada.
Yimiao OuCentre for Research in Neuroscience, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, H3G 1A4Canada.
Lauren Cinq-MarsCentre for Research in Neuroscience, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, H3G 1A4Canada.
Will SilkworthDepartment of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA 90095, USA.
Hannah M BaileyDepartment of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA 90095, USA.
Margot E QuinlanDepartment of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA 90095, USA.
Donald J van MeyelCentre for Research in Neuroscience, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, H3G 1A4Canada.ORCID 0000-0002-6075-8599

Funding

UCLA NIGMS T32 Program AssessmentT32GM007185 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TORRES, JORGE · 1985 to 2020
$21.7M
Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Collaboration between actin nucleators - Spire and CappuccinoR01GM096133 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI QUINLAN, MARGOT E · 2011 to 2024
$4.1M
Canadian Institutes of Health Research (CA) FRN137034CIHR FRN137034McGill UniversityNational Institutes of Health (US) R01GM096133NIGMS NIH HHS R01 GM096133NIGMS NIH HHS T32 GM007185NIH HHS GM007185NIH HHS P40 OD018537NIH HHS R01GM096133Research Institute of the McGill University Health Centre
6 · The paper itself

Abstract

Dendrites form arbors whose size, shape and complexity define how neurons cover their receptive territories. Actin dynamics contribute to growth and remodeling of dendrite arbors. Here, we have examined how Spire, a conserved actin nucleation factor, promotes the formation of new branches in vivo. In live imaging of Drosophila class IV dendritic arborization (c4da) neurons, Spire was observed at new sites of branch initiation, where it assembled new actin polymer in a burst immediately before filopodial outgrowth. For dendrite arborization, Spire required intact structural domains to nucleate actin and target the secretory network, and interacted with Rab11 GTPase, a key regulator of recycling endosomes. Together, these findings support a model in which Spire cooperates with Rab11 to promote new dendrite branches by linking localized actin dynamics with intracellular trafficking of endosomes that deliver lipids and cargoes to fuel protrusive outgrowth of nascent dendrites.

Indexed as

ActinsDendritesDrosophila ProteinsMicrofilament ProteinsAnimalsDrosophila melanogasterEndosomesPolymerizationPseudopodiarab11 GTP-Binding Proteinsrab GTP-Binding ProteinsActinsDrosophila ProteinsMicrofilament Proteinsrab11 GTP-Binding ProteinsRab11 protein, Drosophilarab GTP-Binding ProteinsActinDendriteDrosophila

Identifiers

PMID40937694
PMCPMC12516318

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.