ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2025
Histamine regulates the activity and the expression of the Na
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- The ion transport, GPCR, and RTK toolkit expression in the human cerebrovascular endothelial cell line, hCMEC/D3: an Omics perspective.Frontiers in physiology · 2025Article
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7 authors.
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Abstract
OBJECTIVE AND
designInvestigate the potential role of histamine and its receptors on the functional expression of the sodium/hydrogen (Na MATERIAL: The human epithelial kidney (HK-2) cells were used as an in vitro model of the renal proximal tubule. TREATMENT: HK-2 cells were exposed to histamine 0-1000 nM alone or in combination with chlorphenamine (10 μM) and JNJ-7777120 (1 μM) for 0-48 h. MAPK involvement was determined using the selective inhibitors SB202190 (p38 MAPK), PD98059 (ERK1/2), and SP600125 (SAPK/JNK).
methodsGene and protein expression were evaluated by qPCR and immunoblotting. The activity of NHE3 was measured by the BCECF-AM-based method.
resultsHistamine (100 nM) induced a concentration-dependent NHE3 gene transcription with a peak 16 h after the treatment, followed by protein translation at 48 h after. A Consistent increase in NHE3 activity was observed at 48 h, but also at 60 min, when both p38 MAPK and ERK1/2 were phosphorylated. JNJ-7777120 blunted the activation and expression of NHE3. Chlorpheniramine was effective only on NHE3 activity.
conclusionsHistamine shows early (within 60 min) and late (48 h) effects on NHE3 expression. The histamine H
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