ReviewDrug delivery and translational research2025
Application and development prospects of bio-based smart responsive hydrogels in insulin delivery.
Review in Drug delivery and translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Data-Driven Development of Biomedical Hydrogels for Controlled Drug Delivery: Clinical Applications and Emerging Machine-Learning Approaches.Journal of functional biomaterials · 2026Review
- Conjugation of hydrazine to PEGylated silica-coated magnetite nanoparticles as pH-responsive magnetic nanocarriers for covalent loading and controlled release of doxorubicin.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The increasing prevalence of diabetes has made insulin formulations a cornerstone in the management of the disease. However, traditional insulin delivery methods, such as subcutaneous and intravenous injections, face several challenges, including the need for frequent administration, insulin resistance, and the risk of hypoglycemia. This review examines the use of hydrogels in insulin delivery, with focus on recent advancements in the precise control of insulin release through smart response mechanisms, including pH, glucose, and temperature. The crosslinking methods and polymer compositions of hydrogels are pivotal in enhancing their biocompatibility, mechanical properties, and release regulation. Moreover, composite systems incorporating various carriers, such as nanoparticles, liposomes, and microneedles, offer significant improvements in insulin loading capacity and stable release profiles. The review also explores the potential applications of bioinspired designs and machine learning techniques in optimizing hydrogel material properties, reducing the cost of production, and enhancing the safety and efficacy of insulin delivery. Hydrogels have tremendous development space in drug delivery systems, but they face translational challenges. Through analyzing the storage, scale production and regulatory hurdles of hydrogels, this review offers some exploratory solutions. These strategies aim to promote the clinical application of insulin hydrogels and provide safer and more effective treatment options for patients with diabetes.
Indexed as
Identifiers
40938521What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.