Evidence map›Paper›PMID 40938552›Full record

ReviewScience China. Life sciences2025

Mitochondria-lysosome crosstalk in microbial infections.

Qianqian He, Tiantian Huang, Zhihui Chen, Zhou Sha, Haibo Wu

Abstract readReview
PubMed Publisher
In one paragraph

Review in Science China. Life sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Qianqian HeSchool of Life Sciences, Chongqing University, Chongqing, 401331, China.
Tiantian HuangSchool of Life Sciences, Chongqing University, Chongqing, 401331, China.
Zhihui ChenSchool of Life Sciences, Chongqing University, Chongqing, 401331, China.
Zhou ShaSchool of Life Sciences, Chongqing University, Chongqing, 401331, China.
Haibo WuSchool of Life Sciences, Chongqing University, Chongqing, 401331, China. hbwu023@cqu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coordination between different organelles and metabolic cues is crucial for resistance to pathogen invasion. As the core of maintaining cellular metabolism and homeostasis, mitochondria and lysosomes cooperate in the immune responses and elimination of intracellular pathogens. Previous research has focused on the function of one or the other in isolation, ignoring their pervasive interplay. In this review, we discuss the intricate mechanism of mitochondria-lysosome crosstalk and point out the role of AMP-activated protein kinase (AMPK)-transcription factor EB (TFEB) axis in microbial infections. The crosstalk between mitochondria and lysosomes affects cellular key processes, such as autophagy and programmed death, which play an important role in microbial infections.

Indexed as

LysosomesMitochondriaAMP-Activated Protein KinasesAnimalsAutophagyBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsHumansSignal TransductionAMP-Activated Protein KinasesBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsTFEB protein, humanlysosomesMDVsmicrobial infectionsmitochondriamitophagy

Identifiers

PMID40938552

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.