Evidence map›Paper›PMID 40938670›Full record

ArticleJournal of the American Society of Nephrology : JASN2026

Loop Diuretic Dose Intensification versus Adjuvant Thiazide for Diuretic Resistance in Acute Heart Failure: Mechanistic Randomized Controlled Trial.

Veena S Rao, Zachary L Cox, Juan B Ivey-Miranda, Julieta Moreno-Villagomez, Daniela Ramos-Mastache, Christopher Maulion, Lavanya Bellumkonda, Jeffrey Turner, F Perry Wilson, Michael G Shilpak and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Authors' Reply: Refining the Map of Diuretic Resistance in Acute Heart Failure.Journal of the American Society of Nephrology : JASN · 2026
    Article
  3. Refining the Map of Diuretic Resistance in Acute Heart Failure.Journal of the American Society of Nephrology : JASN · 2026
    Article
  4. Heart failure evidence update 2026.Heart failure reviews · 2026
    Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Veena S RaoSection of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.ORCID 0000-0002-1623-3445
Zachary L CoxDepartment of Pharmacy Practice, Lipscomb University College of Pharmacy, Nashville, Tennessee.ORCID 0000-0002-4919-0146
Juan B Ivey-MirandaSection of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.ORCID 0000-0001-8800-7298
Julieta Moreno-VillagomezSection of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.
Daniela Ramos-MastacheFacultad de Estudios Superiores Iztacala, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico.ORCID 0000-0002-7422-3480
Christopher MaulionSection of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.ORCID 0000-0002-2510-4266
Lavanya BellumkondaSection of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.
Jeffrey TurnerSection of Nephrology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.ORCID 0000-0002-5733-949
F Perry WilsonSection of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.ORCID 0000-0002-2633-2412
Michael G ShilpakKidney Health Research Collaborative, Department of Medicine, University of California San Francisco, San Francisco, California.ORCID 0000-0002-9559-204
Michelle M EstrellaKidney Health Research Collaborative, Department of Medicine, University of California San Francisco, San Francisco, California.ORCID 0000-0002-8902-9576
Paul WellingDepartments of Medicine and Physiology, John Hopkins School of Medicine, Baltimore, Maryland.ORCID 0000-0002-0719-8705
Christopher S WilcoxDivision of Nephrology and Hypertension Center, Georgetown University, Washington, DC.ORCID 0000-0003-0943-1037
David H EllisonOregon Clinical and Translational Research Institute, Oregon Health and Science University, Portland, Oregon.ORCID 0000-0003-2915-265
Biff ForbushDepartment of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut.
Jeffrey M TestaniSection of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.

Funding

Mechanisms of diuretic resistance in heart failureR01DK130997 · NIDDK · YALE UNIVERSITY · PI JEFFREY M TESTANI · 2022 to 2026
$3.7M
NHLBI Division of Intramural Research National Institutes of Health (NIH) R01DK130997, R01DK130870, R01HL128973, R01HL139629, R01HL148354NIDDK NIH HHS R01 DK130997
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

diureticsheart failurepharmacology

Identifiers

PMID40938670
PMCPMC12935386

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.