Evidence mapPaperPMID 40938778Full record

ArticleEuropean journal of heart failure2025

Heart failure with preserved ejection fraction in cancer patients and survivors. A scientific statement of the Heart Failure Association of the ESC and the ESC Council of Cardio-Oncology.

Kalliopi Keramida, Teresa Lopez-Fernandez, Markus S Anker, Mark C Petrie, Pietro Ameri, Lisa J Anderson, Jutta Bergler-Klein, Anita Deswal, Dimitrios Farmakis, Borja Ibañez and 12 more

Abstract readConsensus Statement
In one paragraph

Article in European journal of heart failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
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  9. What's new in heart failure? November 2025.European journal of heart failure · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Kalliopi KeramidaCardiology Department, General Anti-Cancer, Oncological Hospital, Agios Savvas, Athens, Greece.ORCID https://orcid.org/0000-0002-9533-6951
Teresa Lopez-FernandezCardio-Oncology Unit, Cardiology Department, IdiPAZ Research Institute, La Paz University Hospital, Madrid, Spain.
Markus S AnkerDepartment of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Campus Benjamin Franklin, Berlin, Germany.
Mark C PetrieSchool of Cardiovascular and Metabolic Health, University of Glasgow, British Heart Foundation Glasgow Cardiovascular Research Centre, Glasgow, UK.
Pietro AmeriDepartment of Internal Medicine, University of Genova, Genoa, Italy.
Lisa J AndersonCardiovascular Clinical Academic Group, Molecular and Clinical Sciences Research Institute, St. George's, University of London, London, UK.
Jutta Bergler-KleinDepartment of Cardiology, University Clinic of Internal Medicine II, Medical University of Vienna, Vienna, Austria.
Anita DeswalDivision of Internal Medicine, Department of Cardiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Dimitrios FarmakisDepartment of Cardiology, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Borja IbañezCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.
Carolyn S P LamNational Heart Centre Singapore, Singapore, Singapore.
Ninian N LangSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
Alexander R LyonCardio-Oncology Service, Royal Brompton Hospital, London, UK.
Mariana MirabelCardiology Department, General Anti-Cancer, Oncological Hospital, Agios Savvas, Athens, Greece.
Brenda MouraArmed Forces Hospital, Porto Portugal; Faculty of Medicine of the University of Porto, Porto, Portugal.
Walter J PaulusDepartment of Physiology and Amsterdam Cardiovascular Sciences, Amsterdam, Amsterdam University Medical Center, The Netherlands.
Amina RakishevaCity Cardiology Center, Almaty, Kazakhstan.
Gianluigi SavareseDepartment of Clinical Science and Education at Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
Michele SenniUniversity of Milano-Bicocca, Milan, Italy.
Carlo Gabriele TocchettiDepartment of Translational Medical Sciences (DISMET), Center for Basic and Clinical Immunology Research (CISI), Interdepartmental Center of Clinical and Translational Sciences (CIRCET), Interdepartmental Hypertension Research Center (CIRIAPA), Federico II University, Naples, Italy.
Marco MetraCardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.
Gerasimos FilippatosDepartment of Cardiology, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.ORCID https://orcid.org/0000-0002-5640-0332

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heart failure with preserved ejection fraction (HFpEF) is increasingly recognized in cancer patients and survivors, yet it remains underdiagnosed and its epidemiology largely unknown. This statement underscores the imperative need to include HFpEF in the cardiotoxicities identified during or after anticancer treatments. It also highlights the prognostic value of pre-existing HFpEF for periprocedural and cardiotoxicity risk and it discusses the challenges in the diagnosis and treatment of HFpEF in cancer patients. It also explores the aetiologic role of anticancer therapies (chemotherapy, targeted and hormonal therapies and radiotherapy) in the pathogenesis of HFpEF. Special emphasis is given on the importance of considering HFpEF from cancer diagnosis throughout treatment and survivorship and provides useful insights for cardiologists and oncologists in the monitoring and management of these patients. Finally, it highlights the key gaps in current knowledge that require further investigation through well-designed research trials to enhance our understanding and improve clinical outcomes.

Indexed as

Cancer SurvivorsHeart FailureMedical OncologyNeoplasmsStroke VolumeAntineoplastic AgentsCardiologyCardio-OncologyCardiotoxicityHumansPrognosisSocieties, MedicalAntineoplastic AgentsCancerCardiotoxicityChemotherapyHeart failure with preserved ejection fractionRadiotherapy

Identifiers

PMID40938778
PMCPMC12765235

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.