Evidence map›Paper›PMID 40939143›Full record

ArticleJournal of medical virology2025

Heterogeneous Evolution Among SARS-CoV-2 Genes and Variants of Concern.

Luis Daniel González-Vázquez, Paula Iglesias-Rivas, David Ferreiro, Miguel Arenas

Abstract read
In one paragraph

Article in Journal of medical virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Luis Daniel González-VázquezCINBIO, Universidade de Vigo, Vigo, Spain.
Paula Iglesias-RivasCINBIO, Universidade de Vigo, Vigo, Spain.
David FerreiroCINBIO, Universidade de Vigo, Vigo, Spain.
Miguel ArenasCINBIO, Universidade de Vigo, Vigo, Spain.ORCID https://orcid.org/0000-0002-0516-2717

Funding

This study was supported by the Fellowship from Xunta de Galicia ED481A-2023/089, programa de axudas á etapa predoutoral da Xunta de Galicia (Consellería de Cultura, Educación, Formación Profesional e Universidades) cofinanciado pola Unión Europea no marco do Programa FSE+ Galicia 2021-2027; Grant CNS2023-144363 funded by MICIU/AEI/10.13039/501100011033 and by European Union NextGenerationEU/PRTR. Funding for open access charge: Universidade de Vigo/CISUG.
6 · The paper itself

Abstract

Challenges persist regarding the influence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on public health, with growing interest in future viral molecular variants. In this context, accurate predictions demand a thorough understanding of the virus's molecular evolution, especially proteins targeted by therapies, where certain discrepancies among studies exist. We analyzed thousands of SARS-CoV-2 genomes to assess the rate of evolution and molecular adaptation in the various SARS-CoV-2 coding regions. We found an overall low genetic diversity along the genome, with fluctuations over time and among genomic regions, and a notable increase in the Omicron variant, especially in the S and ORF6 genes. We also estimated an overall rate of molecular evolution of approximately 10

Indexed as

COVID-19Evolution, MolecularSARS-CoV-2Genetic VariationGenome, ViralHumansPhylogenySelection, GeneticSpike Glycoprotein, CoronavirusSpike Glycoprotein, Coronavirusgenetic diversitymolecular adaptationmolecular evolutionphylogeneticsrates of evolutionSARS‐CoV‐2 genomic regionsvariants of concern

Identifiers

PMID40939143
PMCPMC12431720

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.