Evidence map›Paper›PMID 40939227›Full record

ArticleInternational dental journal2025

Supragingival Plaque Microbial Signatures Between Radiation Related Caries and Common Caries.

Rui-Huan Gan, Jing Qu, Li-Qing Lan, Da-Li Zheng, You-Guang Lu, Ming Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International dental journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rui-Huan GanFujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatological Key lab of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China; Department of Preventive Dentistry, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China.
Jing QuFujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatological Key lab of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China; Department of Preventive Dentistry, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China.
Li-Qing LanFujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatological Key lab of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China; Department of Preventive Dentistry, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China.
Da-Li ZhengFujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatological Key lab of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China.
You-Guang LuFujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatological Key lab of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China; Department of Preventive Dentistry, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China. Electronic address: fjlyg63@fjmu.edu.cn.
Ming ZhangFujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatological Key lab of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China. Electronic address: zhangming@fjmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe clinical manifestations of radiation-related caries (RRC) differ considerably from those of common caries. This study aims to investigate potential differences in the microbial compositions of supragingival plaque between RRC and common caries.

methodsSupragingival plaque samples from 10 RRC and 10 patients with common caries were analyzed using Type IIB Restriction-site Associated DNA sequencing for Microbiome (2bRAD-M). Analyses of microbial diversity, relative abundance and composition were performed. LEfSe analysis was employed to identify differentially abundant species between the 2 groups. Additionally, 24 RRC and 33 common caries samples were examined using qRT-PCR. Species indicators of RRC were identified through random forest analysis. KEGG and COG functional prediction analyses were conducted to assess microbial functional pathways.

results2bRAD-M sequencing revealed a significant enrichment of Prevotella conceptionensis, Treponema vincentii, and 4 Nanoperiomorbus species in the RRC group. These findings were further validated by LEfSe and qRT-PCR analyses, which confirmed the dominance of P. conceptionensis in RRC. Random forest analysis identified P. conceptionensis as a potential biomarker for RRC. The bacterial abundance in RRC samples was higher than in common caries, particularly in pathways related to glucose metabolism, including 6-phosphofructokinase activity and sugar transferases involved in LPS biosynthesis.

conclusionsThis study uniquely identifies distinct microbial signatures in supragingival plaque associated with RRC compared to common caries. Prevotella conceptionensis was identified as a specific pathogenic bacterium linked to RRC. The underlying mechanisms may involve enhanced microbial glucose metabolism and an inflammatory response mediated by ferroptosis.

Indexed as

Dental CariesDental PlaqueMicrobiotaBacteriaFemaleHumansMaleMiddle AgedRadiotherapy2bRAD-MCariesPrevotella conceptionensisRadiation-related caries

Identifiers

PMID40939227
PMCPMC12790045

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.