Evidence map›Paper›PMID 40939252›Full record

ArticleBioorganic & medicinal chemistry2025

Novel tricycle expanded purine nucleosides with pan-viral activity.

Céline Martin-Ghoteimi, Kyle A Davis, Rayane Ghoteimi, Meareg Amare, Meghan V Diefenbacher, Christianna Kutz, Jessica L Smith, Laura J Stevens, Egor Tchesnokov, Simon M Walker and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Molecules (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Céline Martin-GhoteimiDepartment of Chemistry & Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250, USA.
Kyle A DavisDepartment of Chemistry & Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250, USA.
Rayane GhoteimiDepartment of Chemistry & Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250, USA.
Meareg AmareInfluenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53711, USA.
Meghan V DiefenbacherDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Christianna KutzDepartment of Chemistry & Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250, USA.
Jessica L SmithVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006, USA.
Laura J StevensDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Egor TchesnokovDepartment of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada.
Simon M WalkerDepartment of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada.
Mark DenisonDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Matthias GötteDepartment of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada.
Peter HalfmannInfluenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53711, USA.
Alec J HirschVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006, USA.
Timothy P SheahanDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Katherine L Seley-RadtkeDepartment of Chemistry & Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250, USA. Electronic address: kseley@umbc.edu.

Funding

Research Project 1: Coronavirus antiviral lead development and combination testingU19AI171292 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BARIC, RALPH S, WILLSON, TIMOTHY M · 2022 to 2022
$65.5M
Graduate Training at The Chemistry Biology InterfaceT32GM066706 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI SELEY-RADTKE, KATHERINE L, SMITH, AARON T · 2004 to 2023
$3.3M
NIAID NIH HHS U19 AI171292NIGMS NIH HHS T32 GM066706
6 · The paper itself

Abstract

A series of thiophene-expanded tricyclic nucleosides featuring modifications not previously investigated, including sugar and nucleobase modifications, were synthesized as potential antiviral therapeutics. In addition, their corresponding prodrugs were also pursued to probe their potential antiviral activity, as typically prodrugs increase solubility and delivery. Initial interest was focused on ribose analogues as we had previously only synthesized a few compounds, and none had been tested against new viruses, particularly those of pandemic concern. In that regard, CEM-007, showed promising antiviral activity against several viral families. Given this promising lead, the 2'-α-fluoro-2'-β-methyl-modified analogues of CEM-007 were also synthesized for comparison. While 2'-modified analogue CEM-024 showed little to no antiviral activity, several of its prodrugs including CEM-042, CEM-052, CEM-053, CEM-054 and CEM-055, exhibited potent, broad-spectrum antiviral activity across several viral families including flaviviruses, filoviruses, and coronaviruses, with EC

Indexed as

Antiviral AgentsPurine NucleosidesVirusesAnimalsDose-Response Relationship, DrugHumansMicrobial Sensitivity TestsMolecular StructureProdrugsStructure-Activity RelationshipAntiviral AgentsProdrugsPurine NucleosidesAntiviralBroad-spectrumNucleos(t)ideProdrugsTricycle

Identifiers

PMID40939252
PMCPMC12449768

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.