ArticleThe Science of the total environment2025
Wildfire smoke induces GM3 ganglioside lipid accumulation and transcriptomic shifts in mouse lung tissue: A smoke signal story.
Article in The Science of the total environment, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Plasma Lipidomic Signatures Across the Healthy-Pre-COPD-COPD Continuum Identified by Machine Learning.International journal of chronic obstructive pulmonary disease · 2026Observational
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Authors and funding
9 authors.
Funding
Abstract
Wildfire smoke is a growing concern due to continually rising exposures and links to numerous adverse health effects. Lipids are essential regulators of cellular health, yet their changes from wildfire smoke remain uncharacterized. To investigate molecular alterations driven by smoke inhalation, a lipidomic analysis of lung tissue from mice exposed to various wildfire simulations was performed. Smoke condensates were generated from three biomasses (pine needle, pine core, and eucalyptus) combusted under flaming (640 °C) and smoldering (500 °C) conditions. Six mouse groups were subjected to the different smoke condensate exposures, in addition to saline and lipopolysaccharide negative and positive control groups. Lung tissues were collected 4 h post-exposure and analyzed using a multidimensional platform coupling liquid chromatography, ion mobility spectrometry, and mass spectrometry. A total of 355 unique lipids were identified. Statistical comparisons between each wildfire condition and negative controls revealed 4-7 significantly altered lipids per condition (p
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