Evidence map›Paper›PMID 40939591›Full record

ArticleCell2025

Immunometabolic defects of CD8+ T cells disrupt gut barrier integrity in people with HIV.

Upasana Das Adhikari, Leah M Froehle, Alexandra N Pipkin, Heeva Baharlou, Alice H Linder, Palak Shah, Amanda Hussey, Qiming Zhang, Sarah Nyquist, Saleh Khwaled and 19 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Integrated network pharmacology andFrontiers in immunology · 2026
    Article
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Upasana Das AdhikariRagon Institute of Mass General Brigham, MIT and Harvard, Cambridge, MA 02139, USA. Electronic address: udasadhikari@mgh.harvard.edu.
Leah M FroehleRagon Institute of Mass General Brigham, MIT and Harvard, Cambridge, MA 02139, USA.
Alexandra N PipkinRagon Institute of Mass General Brigham, MIT and Harvard, Cambridge, MA 02139, USA.
Heeva BaharlouRagon Institute of Mass General Brigham, MIT and Harvard, Cambridge, MA 02139, USA.
Alice H LinderRagon Institute of Mass General Brigham, MIT and Harvard, Cambridge, MA 02139, USA.
Palak ShahRagon Institute of Mass General Brigham, MIT and Harvard, Cambridge, MA 02139, USA.
Amanda HusseyKoch Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Qiming ZhangKoch Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Sarah NyquistRagon Institute of Mass General Brigham, MIT and Harvard, Cambridge, MA 02139, USA.
Saleh KhwaledKoch Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Fangtao ChiKoch Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Swagata GoswamiKoch Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Sabhyata SedhainKoch Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Salina HussainRagon Institute of Mass General Brigham, MIT and Harvard, Cambridge, MA 02139, USA.
Thomas J DiefenbachRagon Institute of Mass General Brigham, MIT and Harvard, Cambridge, MA 02139, USA.
Benjamin J ReadRagon Institute of Mass General Brigham, MIT and Harvard, Cambridge, MA 02139, USA.
Byungji KimKoch Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Darrell IrvineKoch Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Osaretin AsowataAfrica Health Research Institute, University of KwaZulu Natal, Durban 4001, South Africa.
Mark LadinskyCalifornia Institute of Technology, Pasadena, CA 91125, USA.
Pamela BjorkmanCalifornia Institute of Technology, Pasadena, CA 91125, USA.
Fusi MadelaAfrica Health Research Institute, University of KwaZulu Natal, Durban 4001, South Africa.
Shakeel KaderAfrica Health Research Institute, University of KwaZulu Natal, Durban 4001, South Africa.
Alex K ShalekRagon Institute of Mass General Brigham, MIT and Harvard, Cambridge, MA 02139, USA.
Musie GhebremichaelRagon Institute of Mass General Brigham, MIT and Harvard, Cambridge, MA 02139, USA.
Henrik KloverprisAfrica Health Research Institute, University of KwaZulu Natal, Durban 4001, South Africa.
Alison E RingelRagon Institute of Mass General Brigham, MIT and Harvard, Cambridge, MA 02139, USA; Koch Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Ömer H YilmazKoch Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Douglas S KwonRagon Institute of Mass General Brigham, MIT and Harvard, Cambridge, MA 02139, USA; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address: dkwon@mgh.harvard.edu.

Funding

CHEETAH Center for the Structural Biology of HIV Infection, Restriction, and Viral DynamicsU54AI170856 · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2025 to 2025
$5.5M
Immunometabolic regulation of CD8+ T cell mediated intestinal epithelial cell death in people with HIV (PWH)R01DK133919 · MASSACHUSETTS GENERAL HOSPITAL · 2025 to 2025
$708k
Impact of HIV-associated intestinal CD8+ T cell function in mucosal homeostasisK99DK136365 · MASSACHUSETTS GENERAL HOSPITAL · 2025 to 2025
$90k
NIAID NIH HHS U54 AI170856NIDDK NIH HHS K99 DK136365NIDDK NIH HHS R01 DK126545NIDDK NIH HHS R01 DK133919
6 · The paper itself

Abstract

A hallmark of HIV infection is disruption of intestinal barrier integrity that persists in people with HIV (PWH) despite treatment with antiretroviral therapy (ART). This disruption is central to HIV disease progression, yet the causes remain incompletely understood. We report a mechanism by which immunometabolic defects in colon-resident CD8

Indexed as

CD8-Positive T-LymphocytesHIV InfectionsIntestinal MucosaApoptosisColonEpithelial CellsFatty AcidsFemaleHumansLipid DropletsMaleMiddle AgedPPAR gammaFatty AcidsPPAR gammagut barrier integrityHIVimmune-epithelial interactionimmunometabolismintestinal epithelial cellstissue resident CD8+T cells

Identifiers

PMID40939591
PMCPMC12641501

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.