Evidence map›Paper›PMID 40939985›Full record

ArticleMethods (San Diego, Calif.)2025

Optimization of

Jarrod Laro, Monica Ness, Joseane Godinho, Randy Coats, Laura-Isobel McCall

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Methods (San Diego, Calif.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Urinary metabolome dynamics inMetabolomics : Official journal of the Metabolomic Society · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jarrod LaroDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA; Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182, USA.
Monica NessDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA; Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182, USA.
Joseane GodinhoDepartment of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182, USA.
Randy CoatsDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA.
Laura-Isobel McCallDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, USA; Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182, USA. Electronic address: lmcall@sdsu.edu.

Funding

Deciphering the mechanism of action of carnitine, a novel treatment for chronic Chagas diseaseR01AI170605 · NIAID · UNIVERSITY OF OKLAHOMA · PI Laura-Isobel McCall · 2022 to 2026
$2.3M
NIAID NIH HHS R01 AI170605
6 · The paper itself

Abstract

The tricarboxylic acid cycle (TCA), also known as the Krebs Cycle or the citric acid cycle, is an essential metabolic pathway involved in energy production that is often impacted by disease, making it of key interest to identify effective, affordable, and simple ways to monitor the impact of disease on TCA metabolism.

Indexed as

Carbon IsotopesCitric Acid CycleIsotope LabelingAnimalsGlucoseLiverMaleMiceMice, Inbred C57BLCarbon-13Carbon IsotopesGlucoseBolusCarbon-13FastingGlucoseLabelingMiceTCA cycle

Identifiers

PMID40939985
PMCPMC12870750

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.