SynthesisOtology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology2025
Blood Biomarkers for the Diagnosis of Peripheral Causes of Vestibular Syndrome: A Systematic Review and Meta-Analysis.
Synthesis in Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- The association of dietary inflammatory index with auditory and vestibular disorders in Korean adults: Differential links to peripheral vertigo, hearing loss and tinnitus.Clinics (Sao Paulo, Brazil) · 2026Article
- Evolution of Research on Persistent Postural-Perceptual Dizziness: A Bibliometric and Visualization Analysis from 1994 to 2025.Audiology research · 2026Review
- Patient-Level Modeling of Ménière's Disease vs. Vestibular Migraine: Performance of Speech Discrimination and Caloric-vHIT Dissociation.Journal of clinical medicine · 2026Article
- Association of sleep quality and inner-ear-specific biomarkers Otolin-1 and otoconin-90 with disease severity in benign paroxysmal positional vertigo.Frontiers in medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPeripheral vestibular syndromes (PVS) encompass disorders such as benign paroxysmal positional vertigo, vestibular neuritis, and Ménière's disease, presenting with vertiginous symptoms. Existing diagnostic approaches rely on clinical and vestibular function tests but have overlapping presentations and invasive investigations. Blood-based biomarkers may offer a minimally invasive diagnostic alternative.
objectivesThis systematic review and meta-analysis aims to synthesize current evidence on blood-based biomarkers to identify PVS compared with controls.
methodsA literature search was conducted for studies until January 1, 2025, in PubMed, Ovid Medline, and EMBASE databases analyzing blood-based biomarkers for PVS versus controls. The QUADAS-2 assessed study quality and a meta-analysis was conducted on biomarkers reported by at least two studies. Pooled standardized mean differences (SMD) with 95% confidence intervals were calculated, and heterogeneity was assessed using the I2 statistic.
resultsThirty-four studies (2,857 PVS, 3,249 controls) met the inclusion criteria where 75 biomarkers were identified and 31 meta-analyzed. Significant differences between PVS and controls were identified for otolin-1 (SMD, 1.53; 95% CI, 0.95 to 2.12), 25-OH vitamin D (SMD, -0.47; 95% CI, -0.76 to -0.19), C-reactive protein (SMD, 0.86; 95% CI, 0.35 to 1.37), leukocyte counts (SMD, 0.45; 95% CI, 0.18 to 0.72), neutrophil counts (SMD, 0.85; 95% CI, 0.44 to 1.25), and the neutrophil-to-lymphocyte ratio (SMD, 0.80; 95% CI, 0.48 to 1.12).
conclusionsInner ear-specific protein (otolin-1) and inflammatory markers (e.g., CRP, fibrinogen, leukocyte/neutrophil counts, and NLR) demonstrated potential diagnostic utility for PVS. Larger, prospective studies should confirm these findings, establish normative values, and explore combined biomarker panels to enhance diagnostic accuracy in PVS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.